Cyclin D2 Products
(Cyclin D2 (CCND2))
Categories
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008].
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Featured Cyclin D2 Categories
Cyclin D2 Antibodies
High quality antibodies with extensive validation data.
Cyclin D2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Cyclin D2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Cyclin D2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (6)
Cat. No.
ABIN738366
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7439681
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (6)
Cat. No.
ABIN7153389
Quantity
100 μL
Datasheet
Datasheet
Recommended Cyclin D2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966159
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966158
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966157
Quantity
96 tests
Datasheet
Datasheet
Recommended Cyclin D2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348447
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348449
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505225
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Cyclin D2 products
: "Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation." in: Biochimica et biophysica acta, Vol. 1864, Issue 4, pp. 634-644, (2017) (PubMed).: "CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling." in: Journal of hematology & oncology, Vol. 9, Issue 1, pp. 124, (2017) (PubMed).
: "The Silencing of CCND2 by Promoter Aberrant Methylation in Renal Cell Cancer and Analysis of the Correlation between CCND2 Methylation Status and Clinical Features." in: PLoS ONE, Vol. 11, Issue 9, pp. e0161859, (2016) (PubMed).
: "Reduced expression of microRNA‑206 regulates cell proliferation via cyclinD2 in gliomas." in: Molecular medicine reports, Vol. 11, Issue 5, pp. 3295-300, (2016) (PubMed).
: "miR-198 Represses the Proliferation of HaCaT Cells by Targeting Cyclin D2." in: International journal of molecular sciences, Vol. 16, Issue 8, pp. 17018-28, (2016) (PubMed).
: "Characterization of the human oncogene SCL/TAL1 interrupting locus (Stil) mediated Sonic hedgehog (Shh) signaling transduction in proliferating mammalian dopaminergic neurons." in: Biochemical and biophysical research communications, Vol. 449, Issue 4, pp. 444-8, (2014) (PubMed).
: "HNF4? is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer." in: Gut, (2014) (PubMed).
: "Elevated toll-like receptor 3 inhibits pancreatic ?-cell proliferation through G1 phase cell cycle arrest." in: Molecular and cellular endocrinology, Vol. 377, Issue 1-2, pp. 112-22, (2013) (PubMed).
: "RNA deep sequencing as a tool for selection of cell lines for systematic subcellular localization of all human proteins." in: Journal of proteome research, Vol. 12, Issue 1, pp. 299-307, (2013) (PubMed).
: "Mouse development and cell proliferation in the absence of D-cyclins." in: Cell, Vol. 118, Issue 4, pp. 477-91, (2004) (PubMed).
Synonyms and alternative names related to Cyclin D2
cyclin D2, b (ccnd2b), cyclin D2 S homeolog (ccnd2.S), cyclin D2 (CCND2), cyclin D2 (ccnd2), G1/S-specific cyclin-D2 (ccnd2), cyclin D2, a (ccnd2a), cyclin D2 (Ccnd2), cyclin D2 L homeolog (ccnd2.L), 2600016F06Rik, AI256817, BF642806, C86853, ccnd2, CCND2, cD2, kiak0002, KIAK0002, LOC100224096, si:ch211-240j22.2, Vin-1, Vin1, zgc:162280Protein level used designations for Cyclin D2
- cyclin D2
- G1/S-specific cyclin-D2
- ccnd2
- G1/S-specific cyclin D2
- vin-1 proto-oncogene
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