Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Cullin 1 Products

(Cullin 1 (CUL1))
Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured Cullin 1 Categories

Cullin 1 Antibodies

High quality antibodies with extensive validation data.

Cullin 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Cullin 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Cullin 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
  • (6)
Cat. No. ABIN3015864
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7180924
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6261114
Quantity 100 μL
Datasheet Datasheet

Recommended Cullin 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381059
Quantity 96 tests
Datasheet Datasheet

Recommended Cullin 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1350756
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122515
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN667243
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Cullin 1 products

Mao, Xiong, Huang, Zheng, Yao: "Expression of CUL1 correlates with tumour-grade and recurrence in urothelial carcinoma." in: ANZ journal of surgery, Vol. 87, Issue 7-8, pp. 624-629, (2018) (PubMed).

Benesova, Kinterova, Kanka, Toralova: "Potential Involvement of SCF-Complex in Zygotic Genome Activation During Early Bovine Embryo Development." in: Methods in molecular biology (Clifton, N.J.), Vol. 1605, pp. 245-257, (2018) (PubMed).

Chen, Xu, Yang, Zhang, Wu, Chen, Li, Wang, Li, Li, Dai: "Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity." in: Experimental & molecular medicine, Vol. 49, Issue 6, pp. e348, (2018) (PubMed).

Lutz, Pace, Arnold: "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." in: Journal of virology, Vol. 90, Issue 13, pp. 6036-48, (2016) (PubMed).

Liao, Jiang, He, Ni, Tu, Zhang, Wang, Lou, Quan, Wang: "NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization." in: Human reproduction (Oxford, England), Vol. 30, Issue 7, pp. 1665-76, (2016) (PubMed).

Jiang, He, Xu, Liu, Qu, Tong: "Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer." in: International journal of clinical and experimental pathology, Vol. 8, Issue 2, pp. 1575-83, (2015) (PubMed).

Wang, Zhao, Zhao, Zhang, Gao: "TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004726, (2015) (PubMed).

Mallampalli, Glasser, Coon, Chen: "Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 4, pp. 663-73, (2013) (PubMed).

Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: "Structural basis for a reciprocal regulation between SCF and CSN." in: Cell reports, Vol. 2, Issue 3, pp. 616-27, (2012) (PubMed).

Duda, Borg, Scott, Hunt, Hammel, Schulman: "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation." in: Cell, Vol. 134, Issue 6, pp. 995-1006, (2008) (PubMed).

Synonyms and alternative names related to Cullin 1

cullin 1 (CUL1), cullin-1 (LOC100282292), cullin 1 (cul1), cullin-1 (ATEG_00491), cullin-1 (EDI_072700), cullin-1 (EDI_264400), Cullin 1 (SJAG_02591), Cullin-1 (BDBG_03785), cullin 1 (Cul1), cullin 1a (cul1a), cullin 1 S homeolog (cul1.S), Cullin-1 (cul-1), cullin 1b (cul1b), ATCUL1, AUXIN RESISTANT 6, AXR6, Cul-1, Cul1, cul1, Cullin-1, cullin-1, cullin 1, LOC100282292, T10P11.26, T10P11_26, wu:fc13a10, wu:fi43h07, wu:fj43a08, zgc:55483, zgc:55747, zgc:77500, zgc:111899

Protein level used designations for Cullin 1

  • CUL-1
  • cullin-1
  • Cullin-1
  • Cell division control 53 homolog
You are here:
Support