CTNNA1 Products
(Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
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Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
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Featured CTNNA1 Categories
CTNNA1 Antibodies
High quality antibodies with extensive validation data.
CTNNA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
CTNNA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CTNNA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (7)
Cat. No.
ABIN6260492
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (8)
Cat. No.
ABIN6139202
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN7261582
Quantity
200 μL
Datasheet
Datasheet
Recommended CTNNA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954435
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380986
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative
Validations
Cat. No.
ABIN778448
Quantity
96 tests
Datasheet
Datasheet
Recommended CTNNA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350658
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350660
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7412980
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CTNNA1 products
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).: "DLC1 interaction with ?-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity." in: Molecular and cellular biology, Vol. 32, Issue 11, pp. 2145-59, (2012) (PubMed).
: "Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18252-9, (2009) (PubMed).
: "Deconstructing the cadherin-catenin-actin complex." in: Cell, Vol. 123, Issue 5, pp. 889-901, (2005) (PubMed).
: "Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly." in: Cell, Vol. 123, Issue 5, pp. 903-15, (2005) (PubMed).
: "Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12758-65, (2005) (PubMed).
: "Gastric cancer: new genetic developments." in: Journal of surgical oncology, Vol. 90, Issue 3, pp. 114-33; discussion 133, (2005) (PubMed).
: "Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma." in: World journal of gastroenterology, Vol. 10, Issue 22, pp. 3235-9, (2005) (PubMed).
: "Characterization of cadherin-24, a novel alternatively spliced type II cadherin." in: The Journal of biological chemistry, Vol. 278, Issue 30, pp. 27513-9, (2003) (PubMed).
: "Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2381-6, (2001) (PubMed).
Synonyms and alternative names related to CTNNA1
catenin alpha 1 (CTNNA1), catenin (cadherin associated protein), alpha 1 (Ctnna1), catenin alpha 1 (Ctnna1), alpha Catenin (alpha-Cat), alpha Catenin (Dgri\alpha-Cat), catenin alpha-1 (Tsp_10127), catenin (cadherin-associated protein), alpha 1 (ctnna1), catenin alpha 1 S homeolog (ctnna1.S), 2010010M04Rik, a-Cat, a-cat, AA517462, AI988031, alpha-CAT, alpha-cat, Alpha-Cat, alpha-catenin, alpha-ctn, alphaCAT, alphaCat, alphacat, CAP102, cap102, Catna1, catna1, CG17947, CT39986, ctnna, ctnna1, Dalpha-Cat, Dalpha-cat, DalphaC, Dalphacat, DgriGH19548, dgri_GLEANR_3829, Dmcatp, Dmel\\CG17947, GH19548Protein level used designations for CTNNA1
- alpha E-catenin
- alpha-E-catenin
- alpha-catenin
- alphaE-catenin
- cadherin-associated protein,102kDa
- catenin alpha-1
- renal carcinoma antigen NY-REN-13
- a-catenin
- 102 kDa cadherin-associated protein
- CAP102
- alpha E catenin
- alpha(E)-catenin
- cadherin associated protein
- catenin alpha 1
- catenin (cadherin associated protein), alpha 1
- catenin, alpha 1
- CG17947-PA
- D-alpha-catenin
- Dalpha-Catenin
- Dalpha-cadherin
- DalphaCatenin
- alpha catenin
- alpha-Cat-PA
- alpha-Catenin
- alphaCatenin
- catenin alpha 1 subunit
- DgriGH19548-PA
- Dgrialpha-Cat-PA
- GH19548-PA
- catenin (cadherin-associated protein), alpha 1, 102kDa
- catenin alpha-1-like
- [a]E-catenin
- catenin alpha 1 S homeolog
- LOW QUALITY PROTEIN: catenin alpha-1
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