CSK Products
(C-Src tyrosine Kinase (CSK))
Categories
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
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Featured CSK Categories
CSK Antibodies
High quality antibodies with extensive validation data.
CSK ELISA Kits
Reliable ELISA kits for a wide range of species.
CSK Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CSK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IP, IHC (p), RNAi
Validations
- (8)
Cat. No.
ABIN560501
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN7101334
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC, FACS
Validations
- (3)
- (3)
Cat. No.
ABIN969069
Quantity
100 μL
Datasheet
Datasheet
Recommended CSK ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965267
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380162
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4886032
Quantity
96 tests
Datasheet
Datasheet
Recommended CSK Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1350517
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350519
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5853916
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CSK products
: "SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91582, (2014) (PubMed).: "Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase." in: Scientific reports, Vol. 3, pp. 926, (2013) (PubMed).
: "Beta-catenin inhibits melanocyte migration but induces melanoma metastasis." in: Oncogene, Vol. 32, Issue 17, pp. 2230-8, (2013) (PubMed).
: "Genome-wide association study of blood pressure and hypertension. ..." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, (2010) (PubMed).
: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." in: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, (2010) (PubMed).
: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, (2009) (PubMed).
: "SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines." in: The American journal of pathology, Vol. 170, Issue 1, pp. 366-76, (2007) (PubMed).
: "Functions of the activation loop in Csk protein-tyrosine kinase." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24072-7, (2003) (PubMed).
: "Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 9, pp. 4767-75, (2003) (PubMed).
: "Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6234-43, (2003) (PubMed).
Synonyms and alternative names related to CSK
C-terminal Src kinase (CSK), c-src tyrosine kinase (Csk), C-terminal Src kinase (Csk), c-src tyrosine kinase (CSK), CSK, non-receptor tyrosine kinase (CSK), AW212630Protein level used designations for CSK
- C-Src kinase
- protein-tyrosine kinase CYL
- tyrosine-protein kinase CSK
- p50CSK
- protein-tyrosine kinase MPK-2
- C-SRC kinase
- protein-tyrosine kinase (CSK)
- protein kinase
- src kinase
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