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CRLF2 Products

(Cytokine Receptor-Like Factor 2 (CRLF2))
The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Featured CRLF2 Categories

CRLF2 Antibodies

High quality antibodies with extensive validation data.

CRLF2 ELISA Kits

Reliable ELISA kits for a wide range of species.

CRLF2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CRLF2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7149302
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
  • (2)
Cat. No. ABIN749738
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN528528
Quantity 100 μg
Datasheet Datasheet

Recommended CRLF2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1889430
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN2708404
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5692222
Quantity 96 tests
Datasheet Datasheet

Recommended CRLF2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275803
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275802
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275801
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CRLF2 products

Deng, Chen, Zhang, Bian, Gao, Hu, Wang, de Souza, Lu, Pflugfelder, Li: "Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation." in: Mucosal immunology, Vol. 12, Issue 5, pp. 1141-1149, (2019) (PubMed).

Bao, Zhang, Yao, Lu, Tong, Yan, Tu, Yang, Zhou: "Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice." in: International journal of biological sciences, Vol. 13, Issue 4, pp. 492-504, (2018) (PubMed).

Cui, Gao, Me, Xu, Yu: "TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway." in: Investigative ophthalmology & visual science, Vol. 59, Issue 10, pp. 4228-4237, (2018) (PubMed).

Kummola, Ortutay, Chen, Caucheteux, Hämäläinen, Aittomäki, Yagi, Zhu, Pesu, Paul, Junttila: "IL-7Rα Expression Regulates Murine Dendritic Cell Sensitivity to Thymic Stromal Lymphopoietin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 198, Issue 10, pp. 3909-3918, (2017) (PubMed).

Onodera, Kiuchi, Kokubo, Kato, Ogino, Horiuchi, Kanai, Hirahara, Nakayama: "Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 199, Issue 3, pp. 1153-1162, (2017) (PubMed).

Verma, Liu, Michalec, Sripada, Gorska, Alam: "Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9+ and IL-13+ type 2 innate lymphoid cell subpopulations." in: The Journal of allergy and clinical immunology, Vol. 142, Issue 3, pp. 793-803.e8, (2017) (PubMed).

Takahashi, Sugaya, Suga, Oka, Kawaguchi, Miyagaki, Fujita, Sato: "Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma." in: Cancer research, Vol. 76, Issue 21, pp. 6241-6252, (2016) (PubMed).

Wiesner, Specht, Lee, Smith, Mukaremera, Lee, Lee, Elias, Nielsen, Boulware, Bohjanen, Jenkins, Levitz, Nielsen: "Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004701, (2015) (PubMed).

Kubo, Kamekura, Kumagai, Kawata, Yamashita, Mitsuhashi, Kojima, Sugimoto, Yoneta, Sumikawa, Yamashita, Sato, Himi, Ichimiya: "ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis." in: PLoS ONE, Vol. 9, Issue 8, pp. e105498, (2015) (PubMed).

Ito, Liu, Arima: "Cellular and molecular mechanisms of TSLP function in human allergic disorders--TSLP programs the "Th2 code" in dendritic cells." in: Allergology international : official journal of the Japanese Society of Allergology, Vol. 61, Issue 1, pp. 35-43, (2012) (PubMed).

Synonyms and alternative names related to CRLF2

cytokine receptor like factor 2 (CRLF2), cytokine receptor-like factor 2 (Crlf2), CRL2, Crl2, CRLF2, CRLF2Y, CRLM2, Ly114, Tpte2, TSLPR, Tslpr

Protein level used designations for CRLF2

  • cytokine receptor-like factor 2
  • IL-XR
  • P2RY8/CRLF2 fusion
  • TSLP receptor
  • cytokine receptor CRL2 precusor
  • cytokine receptor-like 2
  • thymic stromal lymphopoietin protein receptor
  • thymic stromal lymphopoietin receptor
  • thymic stromal-derived lymphopoietin receptor
  • CRLM-2
  • cytokine receptor-like molecule 2
  • delta 1
  • lymphocyte antigen 114
  • thymic stromal-derived lymphopoietin, receptor
  • transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  • type I cytokine receptor delta 1
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