Crk Products
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008].
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Featured Crk Categories
Crk Antibodies
High quality antibodies with extensive validation data.
Crk ELISA Kits
Reliable ELISA kits for a wide range of species.
Crk Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Crk Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, ICC, FACS
Validations
- (2)
- (7)
Cat. No.
ABIN969062
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (4)
Cat. No.
ABIN6256674
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, PLA
Validations
- (4)
Cat. No.
ABIN514602
Quantity
100 μg
Datasheet
Datasheet
Recommended Crk ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971097
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380115
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5691928
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended Crk Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125676
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350363
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350365
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Crk products
: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).: "Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions." in: Proteomics, Vol. 13, Issue 14, pp. 2125-34, (2013) (PubMed).
: "Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation." in: Molecular cancer research : MCR, Vol. 7, Issue 9, pp. 1582-92, (2009) (PubMed).
: "[Biological roles of signaling adaptor protein CRK]." in: Seikagaku. The Journal of Japanese Biochemical Society, Vol. 81, Issue 5, pp. 361-76, (2009) (PubMed).
: "Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling." in: The Journal of biological chemistry, Vol. 283, Issue 9, pp. 5719-27, (2008) (PubMed).
: "Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4." in: Biochemical and biophysical research communications, Vol. 362, Issue 4, pp. 976-81, (2007) (PubMed).
: "The carboxyl-terminal SH3 domain of the mammalian adaptor CrkII promotes internalization of Listeria monocytogenes through activation of host phosphoinositide 3-kinase." in: Cellular microbiology, Vol. 9, Issue 10, pp. 2497-516, (2007) (PubMed).
: "RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase." in: Cancer research, Vol. 67, Issue 1, pp. 381-90, (2007) (PubMed).
: "Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in focal adhesion turnover and integrin activation." in: Experimental cell research, Vol. 295, Issue 1, pp. 258-68, (2004) (PubMed).
: "Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells." in: The Journal of cell biology, Vol. 166, Issue 2, pp. 225-35, (2004) (PubMed).
Synonyms and alternative names related to Crk
Crk oncogene (Crk), v-crk avian sarcoma virus CT10 oncogene homolog (crk), CRK proto-oncogene, adaptor protein (CRK), CRK proto-oncogene, adaptor protein (Crk), v-crk avian sarcoma virus CT10 oncogene homolog L homeolog (crk.L), v-crk sarcoma virus CT10 oncogene homolog (CRK), v-crk avian sarcoma virus CT10 oncogene homolog (Crk), c-Crk, CG1587, CRK, crk, Crk-I, Crk-II, Crk-III, crk2, Crk3, CRKII, crkII, CrkIII, Crko, D-CRK, D-Crk, DCrk, Dcrk, dCRK, dCrk, Dmel\\CG1587, fb34h10, fc05a01, fi19g05, p38, P38C-CRK, v-crk, wu:fb34h10, wu:fc05a01, wu:fc54a04, wu:fi19g05, zgc:100936Protein level used designations for Crk
- CG1587-PA
- CG1587-PB
- CG1587-PC
- CG1587-PD
- CG1587-PE
- CG1587-PF
- Crk-PA
- Crk-PB
- Crk-PC
- Crk-PD
- Crk-PE
- Crk-PF
- adapter molecule crk
- v-crk sarcoma virus CT10 oncogene homolog (avian)
- proto-oncogene c-Crk
- avian sarcoma virus CT10 (v-crk) oncogene homolog
- p38
- proto-oncogene C-crk
- v-crk sarcoma virus CT10 oncogene homolog
- SH2/SH3 adaptor Crk2
- SH2/SH3 adaptor crk
- CT-10 related kinase 3
- proto-oncogene c-crk
- v-crk sarcoma virus CT10 oncogene-like protein
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