Cortactin Products
(Cortactin (CTTN))
Categories
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010].
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Featured Cortactin Categories
Cortactin Antibodies
High quality antibodies with extensive validation data.
Cortactin ELISA Kits
Reliable ELISA kits for a wide range of species.
Cortactin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Cortactin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (5)
- (1)
Cat. No.
ABIN2854674
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (6)
Cat. No.
ABIN6139243
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (7)
Cat. No.
ABIN7266511
Quantity
100 μL
Datasheet
Datasheet
Recommended Cortactin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380549
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380550
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6384450
Quantity
96 tests
Datasheet
Datasheet
Recommended Cortactin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350743
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350741
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
- (1)
Cat. No.
ABIN2712518
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our Cortactin products
: "Clinical Characteristics of Patients With Double-Seronegative Myasthenia Gravis and Antibodies to Cortactin." in: JAMA neurology, Vol. 73, Issue 9, pp. 1099-104, (2016) (PubMed).: "PDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk." in: Acta neuropathologica, Vol. 130, Issue 5, pp. 731-50, (2015) (PubMed).
: "Identification of a novel myositis-associated antibody directed against cortactin." in: Autoimmunity reviews, Vol. 13, Issue 10, pp. 1008-12, (2014) (PubMed).
: "Cortactin autoantibodies in myasthenia gravis." in: Autoimmunity reviews, Vol. 13, Issue 10, pp. 1003-7, (2014) (PubMed).
: "Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2V?2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 3, pp. 1029-42, (2013) (PubMed).
: "Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif." in: The Journal of biological chemistry, Vol. 286, Issue 50, pp. 43039-44, (2011) (PubMed).
: "Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases." in: Molecular biology of the cell, Vol. 20, Issue 14, pp. 3209-23, (2009) (PubMed).
: "Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells." in: Cell and tissue research, Vol. 337, Issue 1, pp. 91-102, (2009) (PubMed).
: "[Expression and clinical significance of EMS1 gene in gastric carcinoma]." in: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 27, Issue 3, pp. 323-6, (2008) (PubMed).
: "Association of cortactin, fascin-1 and epidermal growth factor receptor (EGFR) expression in ovarian carcinomas: correlation with clinicopathological parameters." in: Disease markers, Vol. 25, Issue 1, pp. 17-26, (2008) (PubMed).
Synonyms and alternative names related to Cortactin
cortactin (CTTN), cortactin (Cttn), CG3637 gene product from transcript CG3637-RD (Cortactin), cortactin S homeolog (cttn.S), cortactin L homeolog (cttn.L), cortactin (cttn), src substrate cortactin (CpipJ_CPIJ006351), Src substrate cortactin (Bm1_57220), cortactin (LOC100533277), 1110020L01Rik, CG3637, cortactin, cttn, Cttn, CTTN, CTTN1, Cttnb, Dmel\CG3637, EMS1, Ems1, ems1, P85.25Protein level used designations for Cortactin
- 1110020L01Rik
- amplaxin
- ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
- oncogene EMS1
- src substrate cortactin
- mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
- cortactin isoform B
- CG3637-PA
- CG3637-PB
- CG3637-PC
- CG3637-PD
- Cortactin-PA
- Cortactin-PB
- Cortactin-PC
- Cortactin-PD
- DCortactin
- cortactin
- p80
- p80/85
- src substrate protein p85
- Src substrate cortactin
- src substrate cortactin-like
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