Complement Factor B Products
(Complement Factor B (CFB))
Categories
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008].
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Featured Complement Factor B Categories
Complement Factor B Antibodies
High quality antibodies with extensive validation data.
Complement Factor B ELISA Kits
Reliable ELISA kits for a wide range of species.
Complement Factor B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Complement Factor B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IF
Validations
- (7)
Cat. No.
ABIN3015550
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7438322
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7438376
Quantity
100 μL
Datasheet
Datasheet
Recommended Complement Factor B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (6)
Cat. No.
ABIN6720575
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
- (4)
Cat. No.
ABIN6730898
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
Cat. No.
ABIN6720576
Quantity
96 tests
Datasheet
Datasheet
Recommended Complement Factor B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7092743
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN5854833
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Human Cells
Validations
Cat. No.
ABIN1096421
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Complement Factor B products
: "Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3." in: International journal of molecular sciences, Vol. 21, Issue 4, (2020) (PubMed).: "Identification of susceptibility locus shared by IgA nephropathy and inflammatory bowel disease in a Chinese Han population." in: Journal of human genetics, Vol. 65, Issue 3, pp. 241-249, (2020) (PubMed).
: "Inhibition of Atypical Protein Kinase C Reduces Inflammation-Induced Retinal Vascular Permeability." in: The American journal of pathology, Vol. 188, Issue 10, pp. 2392-2405, (2018) (PubMed).
: "Viral mimic polyinosine-polycytidylic acid potentiates liver injury in trichloroethylene-sensitized mice - Viral-chemical interaction as a novel mechanism." in: Ecotoxicology and environmental safety, Vol. 155, pp. 101-108, (2018) (PubMed).
: "Adipose tissue complement factor B promotes adipocyte maturation." in: Biochemical and biophysical research communications, Vol. 495, Issue 1, pp. 740-748, (2017) (PubMed).
: "Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis." in: Journal of neuroimmunology, Vol. 295-296, pp. 130-8, (2016) (PubMed).
: "Depression of Complement Regulatory Factors in Rat and Human Renal Grafts Is Associated with the Progress of Acute T-Cell Mediated Rejection." in: PLoS ONE, Vol. 11, Issue 2, pp. e0148881, (2016) (PubMed).
: "Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. ..." in: Hepatology (Baltimore, Md.), Vol. 62, Issue 1, pp. 118-28, (2015) (PubMed).
: "Atypical hemolytic uremic syndrome: Korean pediatric series." in: Pediatrics international : official journal of the Japan Pediatric Society, Vol. 57, Issue 3, pp. 431-8, (2015) (PubMed).
: "Identification and confirmation of differentially expressed fucosylated glycoproteins in the serum of ovarian cancer patients using a lectin array and LC-MS/MS." in: Journal of proteome research, Vol. 11, Issue 9, pp. 4541-52, (2012) (PubMed).
Synonyms and alternative names related to Complement Factor B
complement factor B (CFB), complement factor B (cfb), complement factor B (bf), complement factor B S homeolog (cfb.S), complement factor B L homeolog (cfb.L), complement factor B (bf/c2), complement factor B (LOC100555981), complement factor B (Cfb), AHUS4, AI195813, AI255840, B, BF, bf, Bf, Bf-1, bf/c2, Bf B, bfb-A, BFD, Brre-Bf, C2, CFAB, CFB, Da1-24, FB, Fb, FBI12, GBG, H2-Bf, LOC397725, PBF2, Sp152, zgc:114032Protein level used designations for Complement Factor B
- B-factor, properdin
- C3 proaccelerator
- C3 proactivator
- C3/C5 convertase
- glycine-rich beta glycoprotein
- glycine-rich beta-glycoprotein
- properdin factor B
- complement component factor B
- complement factor B
- complement component 2
- EC-VMFB
- complement factor Bf-1
- Factor B
- alternative-complement pathway C3/C5 convertase
- complement component 2 (within H-2S)
- histocompatibility 2, complement component factor B
- properdin
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