Complement C4 Products
(Complement 4 (C4))
Categories
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
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Featured Complement C4 Categories
Complement C4 Antibodies
High quality antibodies with extensive validation data.
Complement C4 ELISA Kits
Reliable ELISA kits for a wide range of species.
Complement C4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Complement C4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7432859
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7432856
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7444499
Quantity
100 μL
Datasheet
Datasheet
Recommended Complement C4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN6574234
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954985
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965990
Quantity
96 tests
Datasheet
Datasheet
Recommended Complement C4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505809
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505810
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Complement C4 products
: "iTRAQ-based proteomic analysis to identify the molecular mechanism of Zhibai Dihuang Granule in the Yin-deficiency-heat syndrome rats." in: Chinese medicine, Vol. 13, pp. 2, (2018) (PubMed).: "Elevated levels of the complement activation product C4d in bronchial fluids for the diagnosis of lung cancer." in: PLoS ONE, Vol. 10, Issue 3, pp. e0119878, (2015) (PubMed).
: "Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy." in: Molecular immunology, Vol. 65, Issue 2, pp. 302-9, (2015) (PubMed).
: "High C4 gene copy numbers protects against Vogt-Koyanagi-Harada syndrome in Chinese Han." in: The British journal of ophthalmology, Vol. 98, Issue 12, pp. 1733-7, (2014) (PubMed).
: "Complement activation contributes to the injury and outcome of kidney in human anti-glomerular basement membrane disease." in: Journal of clinical immunology, Vol. 33, Issue 1, pp. 172-8, (2013) (PubMed).
: "Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis." in: Arthritis and rheumatism, Vol. 65, Issue 11, pp. 2963-70, (2013) (PubMed).
: "Growth hormone, dehydroepiandrosterone and adiponectin levels in non-alcoholic steatohepatitis: an endocrine signature for advanced fibrosis in obese patients." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 32, Issue 2, pp. 279-86, (2012) (PubMed).
: "Therapeutic potential of DCB-SLE1, an extract of a mixture of Chinese medicinal herbs, for severe lupus nephritis." in: American journal of physiology. Renal physiology, Vol. 301, Issue 4, pp. F751-64, (2011) (PubMed).
: "Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 11, pp. 2605-14, (2007) (PubMed).
: "The intricate role of complement component C4 in human systemic lupus erythematosus." in: Current directions in autoimmunity, Vol. 7, pp. 98-132, (2004) (PubMed).
Synonyms and alternative names related to Complement C4
complement C4B (Chido blood group) (C4B), complement C4A (Rodgers blood group) (C4A), complement component 4A (Rodgers blood group) (C4a), complement 4 (C4), complement component 4A (C4A), complement component 4B (Chido blood group) (C4b), C4, C4-1, C4-2, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4B1, C4B2, C4B3, C4B5, C4B12, C4BD, C4B_2, C4F, C4S, CH, CO4, CPAMD2, CPAMD3, RG, Slp, SsProtein level used designations for Complement C4
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
- Chido form of C4
- basic complement C4
- complement C4-B
- complement C4B1a
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
- C4A anaphylatoxin
- Rodgers form of C4
- acidic C4
- acidic complement C4
- complement C4-A
- complement C4
- complement component 4 (within H-2S)
- complement component 4, gene 1
- complement component 4B (Chido blood group)
- complement component 4B (Childo blood group)
- MHC-linked complement C4
- sex-limited protein
- complement component 4
Did you look for something else?
- Complement C3d
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- COMP
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- Complement Factor I
- Complexin 1
- Complexin 4
- Component of Type IV Secretion System
- COMT1
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