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COMP Products

(Cartilage Oligomeric Matrix Protein (COMP))
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008].

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Featured COMP Categories

COMP Antibodies

High quality antibodies with extensive validation data.

COMP ELISA Kits

Reliable ELISA kits for a wide range of species.

COMP Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended COMP Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (5)
Cat. No. ABIN390893
Quantity 400 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7433240
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN6138864
Quantity 100 μL
Datasheet Datasheet

Recommended COMP ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6720567
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6954397
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6954398
Quantity 96 tests
Datasheet Datasheet

Recommended COMP Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Source
Validations
  • (1)
  • (1)
Cat. No. ABIN1047991
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505321
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7534406
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our COMP products

Wang, Chen, Xiang, Wu, Tang, Ma, Zhang: "ADAMTS7 degrades Comp to fuel BMP2-dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas." in: FEBS open bio, Vol. 10, Issue 9, pp. 1856-1867, (2020) (PubMed).

Idriss, Gamal, Gaber, El-Hakeim, Hammam, Ghandour, Abdelaziz, Goma: "Joint remodeling outcome of serum levels of Dickkopf-1 (DKK1), cartilage oligomeric matrix protein (COMP), and C-telopeptide of type II collagen (CTXII) in rheumatoid arthritis." in: Central-European journal of immunology, Vol. 45, Issue 1, pp. 73-79, (2020) (PubMed).

Zhao, Wang, Kong, Zhao: "Elevated serum cartilage oligomeric matrix protein and the metalloproteinase-ADAMTS7 levels are associated with vascular calcification in maintenance hemodialysis patients." in: Seminars in dialysis, Vol. 33, Issue 4, pp. 322-329, (2020) (PubMed).

Kothari, Sinha, Sardar, Tripathi, Girme, Adhikary, Singh, Maurya, Mishra, Hingorani, Trivedi: "Inhibition of cartilage degeneration and subchondral bone deterioration by Spinacia oleracea in human mimic of ACLT-induced osteoarthritis." in: Food & function, Vol. 11, Issue 9, pp. 8273-8285, (2020) (PubMed).

Jeong, Lee, Kim, Choi, Hwang-Bo, Kim, Kim, Ahn, Kim, Lee, Kim, Kim, Hong, Park, Cha, Choi: "Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate‑induced osteoarthritis rats." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 3841-3848, (2018) (PubMed).

Gu, Yang, Tan, Zhang, Lu, Ma: "Decreased Plasma COMP and Increased Plasma CTX-II Levels in a Chinese Pseudoachondroplasia Family with Novel COMP Mutation." in: BioMed research international, Vol. 2017, pp. 5809787, (2018) (PubMed).

Choudhary, Kothari, Tripathi, Singh, Adhikary, Ahmad, Kumar, Dev, Mishra, Shukla, Maurya, Mishra, Trivedi: "Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate-induced osteoarthritis in rats." in: BMC complementary and alternative medicine, Vol. 18, Issue 1, pp. 69, (2018) (PubMed).

Sun, Liu, Liu, Xu, Li, Meng, Ma, Huang, Li: "MeCP2 Regulates PTCH1 Expression Through DNA Methylation in Rheumatoid Arthritis." in: Inflammation, Vol. 40, Issue 5, pp. 1497-1508, (2018) (PubMed).

Aborehab, El Bishbishy, Refaiy, Waly: "A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis." in: BMC complementary and alternative medicine, Vol. 17, Issue 1, pp. 495, (2017) (PubMed).

Jiao, Wei, Chen, Li, Wang, Li, Guo, Zhang, Wei: "Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint." in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 21, Issue 2, pp. 146-51, (2016) (PubMed).

Synonyms and alternative names related to COMP

cartilage oligomeric matrix protein (COMP), cartilage oligomeric matrix protein (sce3551), cartilage oligomeric matrix protein (CJA_1292), cartilage oligomeric matrix protein (Comp), COMP, EDM1, EPD1, MED, PSACH, THBS5, TSP5

Protein level used designations for COMP

  • cartilage oligomeric matrix protein
  • TSP5
  • cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
  • cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
  • pseudoachondroplasia (epiphyseal dysplasia 1, multiple)
  • thrombospondin-5
  • putative cartilage oligomeric matrix protein
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