COL4a3 Products
(Collagen, Type IV, alpha 3 (COL4A3))
Categories
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010].
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Featured COL4a3 Categories
COL4a3 Antibodies
High quality antibodies with extensive validation data.
COL4a3 ELISA Kits
Reliable ELISA kits for a wide range of species.
COL4a3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended COL4a3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7434707
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
- (2)
Cat. No.
ABIN678128
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Horse, Human, Mouse
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN6746738
Quantity
100 μL
Datasheet
Datasheet
Recommended COL4a3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954946
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5653131
Quantity
96 tests
Datasheet
Datasheet
Recommended COL4a3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7321080
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7395947
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5709311
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our COL4a3 products
: "The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage." in: Acta neuropathologica communications, Vol. 10, Issue 1, pp. 187, (2022) (PubMed).: "T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 11, pp. 1135-1144, (2017) (PubMed).
: "Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression." in: PLoS ONE, Vol. 10, Issue 9, pp. e0137043, (2015) (PubMed).
: "The expression and activity of cathepsins D, H and K in asthmatic airways." in: PLoS ONE, Vol. 8, Issue 3, pp. e57245, (2013) (PubMed).
: "A new anti-tumor strategy based on in vivo tumstatin overexpression after plasmid electrotransfer in muscle." in: Biochemical and biophysical research communications, Vol. 432, Issue 4, pp. 549-52, (2013) (PubMed).
: "The role of TG2 in ECV304-related vasculogenic mimicry." in: Amino acids, Vol. 44, Issue 1, pp. 89-101, (2013) (PubMed).
: "Cellular and transcriptomic analysis of human mesenchymal stem cell response to plasma-activated hydroxyapatite coating." in: Acta biomaterialia, Vol. 8, Issue 4, pp. 1627-38, (2012) (PubMed).
: "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity." in: The Journal of biological chemistry, Vol. 273, Issue 49, pp. 33082-90, (1999) (PubMed).
Synonyms and alternative names related to COL4a3
collagen type IV alpha 3 chain (COL4A3), collagen, type IV, alpha 3 (col4a3), collagen, type IV, alpha 3 (Col4a3), collagen type IV alpha 3 chain (Col4a3), alpha3(IV), zTumstatin, [a]3(IV)Protein level used designations for COL4a3
- type IV collagen alpha 3 chain
- collagen alpha-3(IV) chain
- collagen type IV alpha3 chain
- procollagen, type IV, alpha 3
- tumstatin
- collagen, type IV, alpha 3 (Goodpasture antigen)
- collagen IV, alpha-3 polypeptide
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