CNTNAP2 Products
(Contactin Associated Protein-Like 2 (CNTNAP2))
Categories
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010].
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Featured CNTNAP2 Categories
CNTNAP2 Antibodies
High quality antibodies with extensive validation data.
CNTNAP2 ELISA Kits
Reliable ELISA kits for a wide range of species.
CNTNAP2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CNTNAP2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN652646
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (2)
Cat. No.
ABIN949170
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
Validations
- (1)
Cat. No.
ABIN2017587
Quantity
100 μg
Datasheet
Datasheet
Recommended CNTNAP2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966064
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882106
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730471
Quantity
96 tests
Datasheet
Datasheet
Recommended CNTNAP2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7320203
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413064
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
Cat. No.
ABIN7538789
Quantity
2 x 100 μg
Datasheet
Datasheet
Latest Publications for our CNTNAP2 products
: "Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 19, pp. 6176-81, (2015) (PubMed).: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." in: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).
: "Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture." in: Nature, Vol. 500, Issue 7461, pp. 217-21, (2013) (PubMed).
: "Morvan syndrome: clinical and serological observations in 29 cases." in: Annals of neurology, Vol. 72, Issue 2, pp. 241-55, (2012) (PubMed).
: "Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons." in: The Journal of biological chemistry, Vol. 286, Issue 29, pp. 25835-47, (2011) (PubMed).
: "Molecular microdomains in a sensory terminal, the vestibular calyx ending." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 27, pp. 10101-14, (2011) (PubMed).
: "Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome." in: European journal of human genetics : EJHG, Vol. 19, Issue 2, pp. 186-93, (2011) (PubMed).
: "Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 7, pp. 2480-9, (2010) (PubMed).
: "Human myelin proteome and comparative analysis with mouse myelin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14605-10, (2009) (PubMed).
Synonyms and alternative names related to CNTNAP2
contactin associated protein like 2 (CNTNAP2), contactin associated protein-like 2 (Cntnap2), contactin associated protein-like 2 (CNTNAP2), contactin associated protein like 2b (cntnap2b), contactin associated protein like 2 (cntnap2), contactin associated protein like 2 (Cntnap2), 5430425M22Rik, AUTS15, CASPR, CASPR2, Caspr2, CDFE, MGC145769, MGC147944, MGC147981, mKIAA0868, NRXN4, PTHSL1Protein level used designations for CNTNAP2
- cell recognition molecule Caspr2
- contactin-associated protein-like 2
- homolog of Drosophila neurexin IV
- contactin associated protein-like 2
- novel protein similar to H.sapiens contactin associated protein
- contactin associated protein 2
- contactin-associated protein-like 2-like
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