Cleavage and Polyadenylation Factor I Subunit 1 Products
(Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))
Categories
Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing\; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA- induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).
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Featured Cleavage and Polyadenylation Factor I Subunit 1 Categories
Cleavage and Polyadenylation Factor I Subunit 1 Antibodies
High quality antibodies with extensive validation data.
Cleavage and Polyadenylation Factor I Subunit 1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Cleavage and Polyadenylation Factor I Subunit 1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), ICC, IF
Validations
- (1)
- (3)
Cat. No.
ABIN2856997
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN564760
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN1537107
Quantity
400 μL
Datasheet
Datasheet
Recommended Cleavage and Polyadenylation Factor I Subunit 1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349729
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349731
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3091783
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Cleavage and Polyadenylation Factor I Subunit 1 products
: "miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage." in: Nature communications, Vol. 7, pp. 10954, (2016) (PubMed).Synonyms and alternative names related to Cleavage and Polyadenylation Factor I Subunit 1
cleavage and polyadenylation factor I subunit 1 (Clp1), CLP1, cleavage and polyadenylation factor I subunit (Clp1), cyclin and CBS domain divalent metal cation transport mediator 1 (CNNM1), chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1), cleavage and polyadenylation factor I subunit 1 (CLP1), cleavage and polyadenylation factor I subunit 1 (clp1), cleavage and polyadenylation factor I subunit 1 L homeolog (clp1.L), ACDP1, AI462438, CGP-39, CLP-1, clp1, fa28a12, GP-39, hClp1, Heab, HEAB, RGD1307679, SPC-40, SPS-40, wu:fa28a12, YKL-40Protein level used designations for Cleavage and Polyadenylation Factor I Subunit 1
- ATP/GTP-binding protein
- CLP1, cleavage and polyadenylation factor I subunit, homolog
- polyadenylation factor Clp1
- polynucleotide kinase Clp1
- polyribonucleotide 5'-hydroxyl-kinase Clp1
- pre-mRNA cleavage complex II protein Clp1
- ancient conserved domain protein 1
- ancient conserved domain-containing protein 1
- cyclin-M1
- metal transporter CNNM1
- 39 kDa whey protein
- 40 kDa secretory signalling glycoprotein
- cartilage glycoprotein 39
- cartilage glycoprotein-39
- chitinase-3-like protein 1
- chitinase-like protein 1
- signal processing protein
- signal-processing protein
- homolog of yeast CFIA subunit Clp1p
- Polyadenylation factor Clp1
- Polynucleotide kinase Clp1
- Pre-mRNA cleavage complex II protein Clp1
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