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Cleavage and Polyadenylation Factor I Subunit 1 Products

(Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

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Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing\; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA- induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

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Featured Cleavage and Polyadenylation Factor I Subunit 1 Categories

Cleavage and Polyadenylation Factor I Subunit 1 Antibodies

High quality antibodies with extensive validation data.

Cleavage and Polyadenylation Factor I Subunit 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Cleavage and Polyadenylation Factor I Subunit 1 Antibodies

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Latest Publications for our Cleavage and Polyadenylation Factor I Subunit 1 products

Salzman, Nakamura, Nallur, Dookwah, Metheetrairut, Slack, Weidhaas: "miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage." in: Nature communications, Vol. 7, pp. 10954, (2016) (PubMed).

Synonyms and alternative names related to Cleavage and Polyadenylation Factor I Subunit 1

cleavage and polyadenylation factor I subunit 1 (Clp1), CLP1, cleavage and polyadenylation factor I subunit (Clp1), cyclin and CBS domain divalent metal cation transport mediator 1 (CNNM1), chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1), cleavage and polyadenylation factor I subunit 1 (CLP1), cleavage and polyadenylation factor I subunit 1 (clp1), cleavage and polyadenylation factor I subunit 1 L homeolog (clp1.L), ACDP1, AI462438, CGP-39, CLP-1, clp1, fa28a12, GP-39, hClp1, Heab, HEAB, RGD1307679, SPC-40, SPS-40, wu:fa28a12, YKL-40

Protein level used designations for Cleavage and Polyadenylation Factor I Subunit 1

  • ATP/GTP-binding protein
  • CLP1, cleavage and polyadenylation factor I subunit, homolog
  • polyadenylation factor Clp1
  • polynucleotide kinase Clp1
  • polyribonucleotide 5'-hydroxyl-kinase Clp1
  • pre-mRNA cleavage complex II protein Clp1
  • ancient conserved domain protein 1
  • ancient conserved domain-containing protein 1
  • cyclin-M1
  • metal transporter CNNM1
  • 39 kDa whey protein
  • 40 kDa secretory signalling glycoprotein
  • cartilage glycoprotein 39
  • cartilage glycoprotein-39
  • chitinase-3-like protein 1
  • chitinase-like protein 1
  • signal processing protein
  • signal-processing protein
  • homolog of yeast CFIA subunit Clp1p
  • Polyadenylation factor Clp1
  • Polynucleotide kinase Clp1
  • Pre-mRNA cleavage complex II protein Clp1
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