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CLDN14 Products

(Claudin 14 (CLDN14))

Categories

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010].

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Featured CLDN14 Categories

CLDN14 Antibodies

High quality antibodies with extensive validation data.

CLDN14 ELISA Kits

Reliable ELISA kits for a wide range of species.

CLDN14 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CLDN14 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7147891
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
  • (2)
Cat. No. ABIN1881208
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN184791
Quantity 100 μg
Datasheet Datasheet

Recommended CLDN14 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1742853
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1773757
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1745293
Quantity 96 tests
Datasheet Datasheet

Recommended CLDN14 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1349591
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1349593
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3120231
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CLDN14 products

Dimke, Desai, Borovac, Lau, Pan, Alexander: "Activation of the Ca(2+)-sensing receptor increases renal claudin-14 expression and urinary Ca(2+) excretion." in: American journal of physiology. Renal physiology, Vol. 304, Issue 6, pp. F761-9, (2013) (PubMed).

Sato, Hiraoka, Suzuki, Bai, Kurotani, Yokoyama, Okumura, Cismowski, Lanier, Ishikawa: "Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator." in: The Journal of biological chemistry, Vol. 286, Issue 20, pp. 17766-76, (2011) (PubMed).

Thorleifsson, Holm, Edvardsson, Walters, Styrkarsdottir, Gudbjartsson, Sulem, Halldorsson, de Vegt, dAncona, den Heijer, Franzson, Christiansen, Alexandersen, Rafnar, Kristjansson: "Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density." in: Nature genetics, Vol. 41, Issue 8, pp. 926-30, (2009) (PubMed).

Belguith, Tlili, Dhouib, Ben Rebeh, Lahmar, Charfeddine, Driss, Ghorbel, Ayadi, Masmoudi: "Mutation in gap and tight junctions in patients with non-syndromic hearing loss." in: Biochemical and biophysical research communications, Vol. 385, Issue 1, pp. 1-5, (2009) (PubMed).

Wilcox, Burton, Naz, Riazuddin, Smith, Ploplis, Belyantseva, Ben-Yosef, Liburd, Morell, Kachar, Wu, Griffith, Riazuddin, Friedman: "Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29." in: Cell, Vol. 104, Issue 1, pp. 165-72, (2001) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Synonyms and alternative names related to CLDN14

claudin 14 L homeolog (cldn14.L), claudin 14 (CLDN14), claudin 14 (Cldn14), AI851731, claudin-14, CLDN14, DFNB29

Protein level used designations for CLDN14

  • claudin 14
  • claudin-14
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