Clathrin-Ordered Protein Products
(Clathrin-Ordered Protein (COP))
Categories
Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
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Featured Clathrin-Ordered Protein Categories
Clathrin-Ordered Protein Antibodies
High quality antibodies with extensive validation data.
Recommended Clathrin-Ordered Protein Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN2237945
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
Cat. No.
ABIN2237943
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
Cat. No.
ABIN2237957
Quantity
100 μg
Datasheet
Datasheet
Recommended Clathrin-Ordered Protein Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Staphylococcus epidermidis
Source
Yeast
Validations
Cat. No.
ABIN1637512
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Clathrin-Ordered Protein products
: "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins." in: Cell death and differentiation, Vol. 8, Issue 6, pp. 649-57, (2001) (PubMed).
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