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CHRFAM7A Products

(CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10) and FAM7A (Family with Sequence Similarity 7A, Exons A-E) Fusion (CHRFAM7A))

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The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008].

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Featured CHRFAM7A Categories

CHRFAM7A Antibodies

High quality antibodies with extensive validation data.

Recommended CHRFAM7A Antibodies

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Reactivity
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Datasheet
Reactivity Human
Application WB, ELISA, IHC
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Cat. No. ABIN7147675
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
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  • (1)
  • (2)
Cat. No. ABIN2776280
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
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  • (3)
Cat. No. ABIN6098837
Quantity 100 μL
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Recommended CHRFAM7A ELISA Kits

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Reactivity
Analytical Method
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Cat. No.
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Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6229401
Quantity 96 tests
Datasheet Datasheet

Recommended CHRFAM7A Proteins

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Source
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Reactivity Human
Source Tobacco (Nicotiana tabacum)
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Cat. No. ABIN3100532
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CHRFAM7A products

Martin, Leonard, Hall, Tregellas, Freedman, Olincy: "Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 144B, Issue 5, pp. 611-4, (2007) (PubMed).

Trombino, Cesario, Margaritora, Granone, Motta, Falugi, Russo: "Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway." in: Cancer research, Vol. 64, Issue 1, pp. 135-45, (2004) (PubMed).

Bevilacqua, Nelson: "Endothelial-leukocyte adhesion molecules in inflammation and metastasis." in: Thrombosis and haemostasis, Vol. 70, Issue 1, pp. 152-4, (1993) (PubMed).

García Prats, López Carreira, Martínez-González, Ballestín, Gil, De Prada: "Granular cell basal cell carcinoma. Light microscopy, immunohistochemical and ultrastructural study." in: Virchows Archiv. A, Pathological anatomy and histopathology, Vol. 422, Issue 2, pp. 173-7, (1993) (PubMed).

Groves, Allen, Ross, Ahsan, Barker, MacDonald: "Expression of selectin ligands by cutaneous squamous cell carcinoma." in: The American journal of pathology, Vol. 143, Issue 4, pp. 1220-5, (1993) (PubMed).

Ma, Zarbo, Frierson, Lee: "Comparative immunohistochemical study of primary and metastatic carcinomas of the liver." in: American journal of clinical pathology, Vol. 99, Issue 5, pp. 551-7, (1993) (PubMed).

Narita, Funahashi, Satoh, Watanabe, Sakamoto, Takagi: "Association of expression of blood group-related carbohydrate antigens with prognosis in breast cancer." in: Cancer, Vol. 71, Issue 10, pp. 3044-53, (1993) (PubMed).

Paties, Taccagni, Papotti, Valente, Zangrandi, Aloi: "Apocrine carcinoma of the skin. A clinicopathologic, immunocytochemical, and ultrastructural study." in: Cancer, Vol. 71, Issue 2, pp. 375-81, (1993) (PubMed).

Torii, Nakayama, Harada, Nakao, Nonami, Sakamoto, Watanabe, Ito, Takagi: "Expression of the CD15 antigen in hepatocellular carcinoma." in: Cancer, Vol. 71, Issue 12, pp. 3864-7, (1993) (PubMed).

McCormick, Zetter: "Adhesive interactions in angiogenesis and metastasis." in: Pharmacology & therapeutics, Vol. 53, Issue 2, pp. 239-60, (1992) (PubMed).

Synonyms and alternative names related to CHRFAM7A

CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion (CHRFAM7A), CHRNA7, CHRNA7-DR1, D-10

Protein level used designations for CHRFAM7A

  • CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
  • CHRNA7-FAM7A fusion protein
  • alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid
  • alpha-7 nicotinic cholinergic receptor subunit
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