CHEK1 Products
(Checkpoint Kinase 1 (CHEK1))
Categories
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
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Featured CHEK1 Categories
CHEK1 Antibodies
High quality antibodies with extensive validation data.
CHEK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
CHEK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CHEK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (1)
- (10)
Cat. No.
ABIN6255201
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (7)
Cat. No.
ABIN6255167
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (8)
Cat. No.
ABIN6256255
Quantity
100 μL
Datasheet
Datasheet
Recommended CHEK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954575
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380541
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380542
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended CHEK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349303
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7320012
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7317105
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CHEK1 products
: "Sam68 is required for the growth and survival of nonmelanoma skin cancer." in: Cancer medicine, Vol. 8, Issue 13, pp. 6106-6113, (2019) (PubMed).: "Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma." in: Translational oncology, Vol. 11, Issue 1, pp. 140-146, (2018) (PubMed).
: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." in: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).
: "Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro." in: Archives of toxicology, Vol. 91, Issue 1, pp. 259-270, (2017) (PubMed).
: "Two subunits of human ORC are dispensable for DNA replication and proliferation." in: eLife, Vol. 5, (2017) (PubMed).
: "Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway." in: PLoS pathogens, Vol. 13, Issue 3, pp. e1006266, (2017) (PubMed).
: "TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint." in: BMC molecular biology, Vol. 17, pp. 3, (2016) (PubMed).
: "CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells." in: Nucleic acids research, Vol. 43, Issue 5, pp. 2603-14, (2015) (PubMed).
: "Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney." in: Oncotarget, Vol. 6, Issue 34, pp. 35964-77, (2015) (PubMed).
: "Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy." in: Scientific reports, Vol. 4, pp. 7548, (2015) (PubMed).
Synonyms and alternative names related to CHEK1
checkpoint kinase 1 (CHEK1), serine/threonine-protein kinase chk1 (ANI_1_2436074), serine/threonine-protein kinase chk1 (AOR_1_768154), serine/threonine-protein kinase Chk1 (PTRG_04183), CAMK/CAMKL/CHK1 protein kinase Chk1 (SJAG_01680), serine/threonine-protein kinase chk1 (PAAG_04978), serine/threonine-protein kinase chk1 (MCYG_03290), serine/threonine-protein kinase chk1 (VDBG_03742), checkpoint kinase 1 S homeolog (chek1.S), checkpoint kinase 1 (Chek1), checkpoint kinase 1 (chek1), An08g10320, AO090003000441, C85740, CHEK1, CHK1, chk1, Chk1, id:ibd2720, rad27, zgc:56093Protein level used designations for CHEK1
- CHK1 checkpoint homolog
- Serine/threonine-protein kinase Chk1-like protein
- serine/threonine-protein kinase Chk1
- serine/threonine-protein kinase chk1
- Checkpoint, S. pombe, homolog of, 1
- Chk1-S
- cell cycle checkpoint kinase
- checkpoint kinase-1
- Chk1 checkpoint kinase
- xChk1
- checkpoint kinase 1 homolog
- rad27 homolog
- 2720
- integral membrane protein 1
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