Checkpoint with Forkhead and Ring Finger Domains Products
(Checkpoint with Forkhead and Ring Finger Domains (CHFR))
Categories
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
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Featured Checkpoint with Forkhead and Ring Finger Domains Categories
Checkpoint with Forkhead and Ring Finger Domains Antibodies
High quality antibodies with extensive validation data.
Checkpoint with Forkhead and Ring Finger Domains Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Checkpoint with Forkhead and Ring Finger Domains Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p), RNAi
Validations
- (7)
- (6)
Cat. No.
ABIN565913
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (3)
Cat. No.
ABIN7151005
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, ICC, IF
Validations
- (3)
Cat. No.
ABIN6259505
Quantity
100 μL
Datasheet
Datasheet
Recommended Checkpoint with Forkhead and Ring Finger Domains ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6234620
Quantity
96 tests
Datasheet
Datasheet
Recommended Checkpoint with Forkhead and Ring Finger Domains Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349312
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349314
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3091433
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Checkpoint with Forkhead and Ring Finger Domains products
: "Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach." in: Virchows Archiv : an international journal of pathology, Vol. 460, Issue 2, pp. 163-9, (2012) (PubMed).: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." in: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).
: "Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer." in: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 447-54, (2011) (PubMed).
: "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 643-52, (2008) (PubMed).
: "Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma." in: World journal of gastroenterology : WJG, Vol. 14, Issue 32, pp. 5000-7, (2008) (PubMed).
: "Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis." in: Human pathology, Vol. 38, Issue 6, pp. 903-13, (2007) (PubMed).
: "Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression." in: Cancer research, Vol. 67, Issue 13, pp. 6064-74, (2007) (PubMed).
: "Chfr defines a mitotic stress checkpoint that delays entry into metaphase." in: Nature, Vol. 406, Issue 6794, pp. 430-5, (2000) (PubMed).
Synonyms and alternative names related to Checkpoint with Forkhead and Ring Finger Domains
checkpoint with forkhead and ring finger domains (CHFR), checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr), checkpoint with forkhead and ring finger domains (Chfr), checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L), 5730484M20Rik, C230082M18, CHFR, fc43f10, RNF116, rnf116, RNF196, rnf196, si:dkey-69h6.7, wu:fc43f10Protein level used designations for Checkpoint with Forkhead and Ring Finger Domains
- E3 ubiquitin-protein ligase CHFR
- RING finger protein 196
- checkpoint with forkhead and RING finger domains protein
- checkpoint with forkhead and ring finger domains
- Checkpoint with forkhead and RING finger domains protein
- e3 ubiquitin-protein ligase CHFR-like
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