For best experience we recommend to activate Javascript in your browser.

CDT2/RAMP Proteins

(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

recommended

CDT2/RAMP Protein (AA 1-730) (Strep Tag) (ABIN3092255)

DTL Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB

Show Details

recommended

CDT2/RAMP Protein (AA 1-729) (Strep Tag) (ABIN3134980)

DTL Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB

Show Details

recommended

CDT2/RAMP Protein (GST tag,His tag) (ABIN5505614)

DTL Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining STD, AbP

Show Details

CDT2/RAMP Proteins by Origin

Find CDT2/RAMP Proteins for a variety of species such as anti-Human CDT2/RAMP, anti-Mouse CDT2/RAMP. The species listed below are among those available. Click on a link to go to the corresponding products.

CDT2/RAMP Proteins by Source

Here you will find CDT2/RAMP Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

CDT2/RAMP Proteins by Protein Type

Here you can find CDT2/RAMP Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

CDT2/RAMP Proteins by Application

Find CDT2/RAMP Proteins validated for a specific application such as ELISA, SDS, WB, AbP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular CDT2/RAMP Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

CDT2/RAMP Protein (AA 1-730) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3092255

Quantity 1 mg

Datasheet Datasheet

CDT2/RAMP Protein (AA 1-729) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134980

Quantity 1 mg

Datasheet Datasheet

CDT2/RAMP Protein (GST tag,His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN5505614

Quantity 50 μg

Datasheet Datasheet

Aliases for CDT2/RAMP Proteins

denticleless E3 ubiquitin protein ligase homolog (DTL) Proteins
denticleless E3 ubiquitin protein ligase (Dtl) Proteins
denticleless E3 ubiquitin protein ligase homolog (Dtl) Proteins
denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) Proteins
denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) Proteins
2810047L02Rik Proteins
5730564G15Rik Proteins
cb151 Proteins
CDT2 Proteins
cdt2 Proteins
cdt2-a Proteins
chunp6871 Proteins
DCAF2 Proteins
dcaf2 Proteins
L2DTL Proteins
l2dtl Proteins
RAMP Proteins
Ramp Proteins
ramp Proteins
RGD1310439 Proteins
wu:fb54b02 Proteins

Did you look for something else?

You are here:

CDT2/RAMP Proteins by Origin

CDT2/RAMP Proteins by Source

CDT2/RAMP Proteins by Protein Type

CDT2/RAMP Proteins by Application

Popular CDT2/RAMP Proteins

Aliases for CDT2/RAMP Proteins

Did you look for something else?

antibodies-online

genomics-online