CDT2/RAMP Products
(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
Categories
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
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Featured CDT2/RAMP Categories
CDT2/RAMP Antibodies
High quality antibodies with extensive validation data.
CDT2/RAMP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CDT2/RAMP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7149691
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN654926
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN949333
Quantity
100 μg
Datasheet
Datasheet
Recommended CDT2/RAMP Proteins
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Reactivity
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Validations
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Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092255
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134980
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
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Cat. No.
ABIN5505614
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CDT2/RAMP products
: "Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex." in: Molecular biology of the cell, Vol. 26, Issue 13, pp. 2426-38, (2015) (PubMed).: "Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma." in: Oncotarget, Vol. 6, Issue 34, pp. 36615-24, (2015) (PubMed).
: "Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung." in: Disease models & mechanisms, Vol. 8, Issue 12, pp. 1531-42, (2015) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation." in: The Journal of cell biology, Vol. 192, Issue 1, pp. 43-54, (2011) (PubMed).
: "Prognostic significance of miR-215 in colon cancer." in: Clinical colorectal cancer, Vol. 10, Issue 4, pp. 340-7, (2011) (PubMed).
: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).
Synonyms and alternative names related to CDT2/RAMP
denticleless E3 ubiquitin protein ligase homolog (DTL), denticleless E3 ubiquitin protein ligase (Dtl), denticleless E3 ubiquitin protein ligase homolog (Dtl), denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S), denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl), 2810047L02Rik, 5730564G15Rik, cb151, CDT2, cdt2, cdt2-a, chunp6871, DCAF2, dcaf2, L2DTL, l2dtl, RAMP, Ramp, ramp, RGD1310439, wu:fb54b02Protein level used designations for CDT2/RAMP
- DDB1 and CUL4 associated factor 2
- DDB1- and CUL4-associated factor 2
- RA regulated nuclear matrix associated protein
- RA-regulated nuclear matrix-associated protein
- denticleless homolog
- denticleless protein homolog
- lethal(2) denticleless protein homolog
- retinoic acid-regulated nuclear matrix-associated protein
- Meth A ramp
- meth A retinoic acid-regulated nuclear matrix-associated protein
- retinoic-acid regulated nuclear matrix-associated protein
- denticleless protein homolog A
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