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CDK8 Products

(Cyclin-Dependent Kinase 8 (CDK8))
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008].

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Featured CDK8 Categories

CDK8 Antibodies

High quality antibodies with extensive validation data.

CDK8 ELISA Kits

Reliable ELISA kits for a wide range of species.

CDK8 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CDK8 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (7)
Cat. No. ABIN560302
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (3)
Cat. No. ABIN6138329
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, ICC, IF
Validations
  • (2)
Cat. No. ABIN6257696
Quantity 100 μL
Datasheet Datasheet

Recommended CDK8 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966174
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955161
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955162
Quantity 96 tests
Datasheet Datasheet

Recommended CDK8 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348983
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7407718
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7407715
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CDK8 products

Han, Zheng, Ge, Wang, Xiang, Wang: "Downregulation of cyclin-dependent kinase 8 by microRNA-148a suppresses proliferation and invasiveness of papillary thyroid carcinomas." in: American journal of cancer research, Vol. 7, Issue 10, pp. 2081-2090, (2018) (PubMed).

Li, Tian, Ren, Chen, Wang, Ge, Wu, Sun, Liu, Xiao: "MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8." in: Journal of translational medicine, Vol. 13, pp. 271, (2015) (PubMed).

Zhao, Ramos, Demma: "CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation." in: Oncogene, Vol. 32, Issue 30, pp. 3520-30, (2013) (PubMed).

Barette, Jariel-Encontre, Piechaczyk, Piette: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).

Di Pietro, Rapisarda, Bonaiuto, Lizzio, Engel, Amico, Scalia, Amato, Grzeschik, Sichel, Purrello: "Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7." in: Somatic cell and molecular genetics, Vol. 25, Issue 3, pp. 185-9, (2001) (PubMed).

Akoulitchev, Chuikov, Reinberg: "TFIIH is negatively regulated by cdk8-containing mediator complexes." in: Nature, Vol. 407, Issue 6800, pp. 102-6, (2000) (PubMed).

Johnson, Walker: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).

Rickert, Corden, Lees: "Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases." in: Oncogene, Vol. 18, Issue 4, pp. 1093-102, (1999) (PubMed).

Synonyms and alternative names related to CDK8

cyclin dependent kinase 8 (CDK8), cyclin-dependent kinase 8 (Cdk8), cyclin-dependent kinase 8 (cdk8), cyclin-dependent kinase 8 S homeolog (cdk8.S), Cyclin-dependent kinase 8 (cdk-8), cyclin-dependent kinase 8 (CDK8), cyclin dependent kinase 19 (CDK19), K35, wu:fk95h11

Protein level used designations for CDK8

  • CDK8 protein kinase
  • cell division protein kinase 8
  • mediator complex subunit CDK8
  • mediator of RNA polymerase II transcription subunit CDK8
  • protein kinase K35
  • cyclin-dependent kinase 8
  • mediator complex subunit cdk8
  • mediator of RNA polymerase II transcription subunit cdk8
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