CDK8 Products
(Cyclin-Dependent Kinase 8 (CDK8))
Categories
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008].
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Featured CDK8 Categories
CDK8 Antibodies
High quality antibodies with extensive validation data.
CDK8 ELISA Kits
Reliable ELISA kits for a wide range of species.
CDK8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CDK8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (7)
Cat. No.
ABIN560302
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN6138329
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IF
Validations
- (2)
Cat. No.
ABIN6257696
Quantity
100 μL
Datasheet
Datasheet
Recommended CDK8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966174
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955161
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955162
Quantity
96 tests
Datasheet
Datasheet
Recommended CDK8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348983
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7407718
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7407715
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CDK8 products
: "Downregulation of cyclin-dependent kinase 8 by microRNA-148a suppresses proliferation and invasiveness of papillary thyroid carcinomas." in: American journal of cancer research, Vol. 7, Issue 10, pp. 2081-2090, (2018) (PubMed).: "MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8." in: Journal of translational medicine, Vol. 13, pp. 271, (2015) (PubMed).
: "CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation." in: Oncogene, Vol. 32, Issue 30, pp. 3520-30, (2013) (PubMed).
: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).
: "Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7." in: Somatic cell and molecular genetics, Vol. 25, Issue 3, pp. 185-9, (2001) (PubMed).
: "TFIIH is negatively regulated by cdk8-containing mediator complexes." in: Nature, Vol. 407, Issue 6800, pp. 102-6, (2000) (PubMed).
: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).
: "Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases." in: Oncogene, Vol. 18, Issue 4, pp. 1093-102, (1999) (PubMed).
Synonyms and alternative names related to CDK8
cyclin dependent kinase 8 (CDK8), cyclin-dependent kinase 8 (Cdk8), cyclin-dependent kinase 8 (cdk8), cyclin-dependent kinase 8 S homeolog (cdk8.S), Cyclin-dependent kinase 8 (cdk-8), cyclin-dependent kinase 8 (CDK8), cyclin dependent kinase 19 (CDK19), K35, wu:fk95h11Protein level used designations for CDK8
- CDK8 protein kinase
- cell division protein kinase 8
- mediator complex subunit CDK8
- mediator of RNA polymerase II transcription subunit CDK8
- protein kinase K35
- cyclin-dependent kinase 8
- mediator complex subunit cdk8
- mediator of RNA polymerase II transcription subunit cdk8
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