CDK5R1 Products
(Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
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The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
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Featured CDK5R1 Categories
CDK5R1 Antibodies
High quality antibodies with extensive validation data.
CDK5R1 ELISA Kits
Reliable ELISA kits for a wide range of species.
CDK5R1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CDK5R1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
Cat. No.
ABIN2486463
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
Cat. No.
ABIN2486459
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
Cat. No.
ABIN2486461
Quantity
100 μg
Datasheet
Datasheet
Recommended CDK5R1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966171
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966170
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648251
Quantity
96 tests
Datasheet
Datasheet
Recommended CDK5R1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122534
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN1686721
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348963
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our CDK5R1 products
: "Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 4973-85, (2012) (PubMed).: "Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function." in: The Journal of biological chemistry, Vol. 287, Issue 38, pp. 32277-87, (2012) (PubMed).
: "CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5." in: FEBS letters, Vol. 582, Issue 8, pp. 1197-202, (2008) (PubMed).
: "Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke." in: Brain pathology (Zurich, Switzerland), Vol. 17, Issue 1, pp. 11-23, (2007) (PubMed).
: "Increased immunoreactivity of cdk5 activators in hippocampal sclerosis." in: Neuroreport, Vol. 18, Issue 5, pp. 511-6, (2007) (PubMed).
: "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15571-4, (2001) (PubMed).
: "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies." in: Genes & development, Vol. 14, Issue 4, pp. 422-34, (2000) (PubMed).
: "Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1718-20, (1997) (PubMed).
: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." in: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, (1994) (PubMed).
Synonyms and alternative names related to CDK5R1
cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b), cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1), S100 calcium binding protein A9 (S100A9), cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog (cdk5r1.L), cyclin dependent kinase 5 regulatory subunit 1 (Cdk5r1), CDK5P35, CDK5R, Cdk5r, cdk5r1, CDK5R1, D11Bwg0379e, NCK5A, p23, p25, P25/P35, p35, p35nck5a, Xp35.1, zgc:92814Protein level used designations for CDK5R1
- CDK5 activator 1
- TPKII regulatory subunit
- cyclin-dependent kinase 5 activator 1
- cyclin-dependent kinase 5 regulatory subunit 1
- neuronal CDK5 activator
- regulatory partner for CDK5 kinase
- tau protein kinase II 23kDa subunit
- cyclin-dependent kinase 5 regulatory subunit
- cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- p23
- tau protein kinase II 23 kDa subunit
- BEE22
- S100 calcium-binding protein A9
- calgranulin-B
- neutrophil cytosolic 23 kDa protein
- protein S100-A9
- cyclin-dependent kinase 5, regulatory subunit (p35) 1
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