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CDK14 Products

(Cyclin-Dependent Kinase 14 (CDK14))

Categories

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

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Featured CDK14 Categories

CDK14 Antibodies

High quality antibodies with extensive validation data.

CDK14 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CDK14 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (5)
Cat. No. ABIN390748
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN391791
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN518821
Quantity 50 μg
Datasheet Datasheet

Recommended CDK14 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6224342
Quantity 96 tests
Datasheet Datasheet

Recommended CDK14 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314769
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314767
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424140
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CDK14 products

Wang, Jia, Fei, Song, Li: "Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation." in: The Journal of biological chemistry, Vol. 291, Issue 51, pp. 26427-26434, (2017) (PubMed).

Miyagaki, Yamasaki, Miyata, Takahashi, Kurokawa, Nakajima, Takiguchi, Fujiwara, Ishii, Tanaka, Mori, Doki: "Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma." in: British journal of cancer, Vol. 106, Issue 5, pp. 947-54, (2012) (PubMed).

Quina, Wang, Ng, Turner: "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 45, pp. 14309-22, (2009) (PubMed).

Jiang, Gao, Yang, Zhu, Chen: "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1." in: FEBS letters, Vol. 583, Issue 13, pp. 2171-8, (2009) (PubMed).

Scherer, Cheung, MacDonald, Osborne, Nakabayashi, Herbrick, Carson, Parker-Katiraee, Skaug, Khaja, Zhang, Hudek, Li, Haddad, Duggan, Fernandez, Kanematsu, Gentles, Christopoulos, Choufani, Kwasnicka et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, (2003) (PubMed).

Yang, Chen: "Identification and cellular localization of human PFTAIRE1." in: Gene, Vol. 267, Issue 2, pp. 165-72, (2001) (PubMed).

Synonyms and alternative names related to CDK14

cyclin dependent kinase 14 (CDK14), cyclin-dependent kinase 14 (Cdk14), cyclin-dependent kinase 14 L homeolog (cdk14.L), mKIAA0834, PFTAIRE1, pftaire1, PFTK1, Pftk1, pftk1

Protein level used designations for CDK14

  • PFTAIRE protein kinase 1
  • cell division protein kinase 14
  • hPFTAIRE1
  • serine/threonine-protein kinase PFTAIRE-1
  • Cell division protein kinase 14
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