CD59 Products
(CD59)
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This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
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Featured CD59 Categories
CD59 Antibodies
High quality antibodies with extensive validation data.
CD59 ELISA Kits
Reliable ELISA kits for a wide range of species.
CD59 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD59 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, IHC, ELISA, ICC
Validations
- (2)
- (8)
Cat. No.
ABIN1098134
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IF, IHC (p)
Validations
- (5)
Cat. No.
ABIN6242239
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, IP, IHC (p)
Validations
- (4)
- (4)
Cat. No.
ABIN94199
Quantity
0.1 mg
Datasheet
Datasheet
Recommended CD59 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960667
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965599
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965598
Quantity
96 tests
Datasheet
Datasheet
Recommended CD59 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274197
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7319910
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122212
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CD59 products
: "Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT." in: Molecular biotechnology, (2018) (PubMed).: "A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174074, (2017) (PubMed).
: "Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation." in: Scientific reports, Vol. 6, pp. 26274, (2016) (PubMed).
: "The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events." in: Cell metabolism, Vol. 19, Issue 5, pp. 883-90, (2014) (PubMed).
: "Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?" in: Journal of neuroimmunology, Vol. 276, Issue 1-2, pp. 172-4, (2014) (PubMed).
: "Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease." in: Journal of internal medicine, Vol. 276, Issue 5, pp. 470-85, (2014) (PubMed).
: "Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells." in: Chembiochem : a European journal of chemical biology, Vol. 15, Issue 10, pp. 1393-8, (2014) (PubMed).
: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).
: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).
: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, (2007) (PubMed).
Synonyms and alternative names related to CD59
CD59 molecule (CD59 blood group) (CD59), CD59 molecule (Cd59), CD59 molecule (CD59), 1F5, 16.3A5, Cd59a, Cd59b, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MACIP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20Protein level used designations for CD59
- 1F5 antigen
- 20 kDa homologous restriction factor
- CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
- CD59 glycoprotein
- Ly-6-like protein
- MEM43 antigen
- T cell-activating protein
- human leukocyte antigen MIC11
- lymphocytic antigen CD59/MEM43
- membrane attack complex (MAC) inhibition factor
- membrane attack complex inhibition factor
- membrane inhibitor of reactive lysis
- protectin
- surface anitgen recognized by monoclonal antibody 16.3A5
- CD59 antigen
- CD59b moleucle, complement regulatory protein
- Cb59b molecule
- MAC-inhibitory protein
- MAC-IP
- MACIF
- CD59 homolog
- CD59 molecule, complement regulatory protein
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