CD53 Products
(CD53)
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Featured CD53 Categories
CD53 Antibodies
High quality antibodies with extensive validation data.
CD53 ELISA Kits
Reliable ELISA kits for a wide range of species.
CD53 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD53 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, WB, IHC, ELISA, ICC, Neut
Validations
- (7)
Cat. No.
ABIN7193233
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, WB, IHC, ELISA, ICC, Neut
Validations
- (5)
Cat. No.
ABIN7193232
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS
Validations
- (5)
- (3)
Cat. No.
ABIN192139
Quantity
100 tests
Datasheet
Datasheet
Recommended CD53 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730119
Quantity
96 tests
Datasheet
Datasheet
Recommended CD53 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1329990
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348669
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7320175
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CD53 products
: "The tetraspanin web revisited by super-resolution microscopy." in: Scientific reports, Vol. 5, pp. 12201, (2015) (PubMed).: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).
: "LPS-induced CD53 expression: a protection mechanism against oxidative and radiation stress." in: Molecules and cells, Vol. 17, Issue 1, pp. 125-31, (2004) (PubMed).
: "Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells." in: Kidney international, Vol. 63, Issue 2, pp. 534-42, (2003) (PubMed).
: "CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics." in: International immunology, Vol. 14, Issue 3, pp. 249-58, (2002) (PubMed).
: "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 7, pp. 2939-46, (1996) (PubMed).
: "Enrichment of early fetal-liver hemopoietic stem cells of the rat using monoclonal antibodies against the transferrin receptor, Thy-1, and MRC-OX82." in: Developmental immunology, Vol. 4, Issue 4, pp. 235-46, (1996) (PubMed).
: "Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity." in: European journal of immunology, Vol. 25, Issue 7, pp. 2090-5, (1995) (PubMed).
: "Characterization of mouse CD53: epitope mapping, cellular distribution and induction by T cell receptor engagement during repertoire selection." in: European journal of immunology, Vol. 25, Issue 8, pp. 2201-5, (1995) (PubMed).
: "CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells." in: Blood, Vol. 85, Issue 9, pp. 2402-13, (1995) (PubMed).
Synonyms and alternative names related to CD53
CD53 antigen (Cd53), CD53 molecule (CD53), Cd53 molecule (Cd53), AI323659, MOX44, Ox-44, OX44, Tspan25, TSPAN25Protein level used designations for CD53
- cell surface glycoprotein CD53
- leukocyte surface antigen CD53
- CD53 antigen
- CD53 glycoprotein
- CD53 tetraspan antigen
- antigen MOX44 identified by monoclonal antibody MRC-OX44
- cell surface antigen
- tetraspanin-25
- transmembrane glycoprotein
- tspan-25
- leukocyte antigen MRC OX-44
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