CD46 Products
(CD46)
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The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].
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Featured CD46 Categories
CD46 Antibodies
High quality antibodies with extensive validation data.
CD46 ELISA Kits
Reliable ELISA kits for a wide range of species.
CD46 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD46 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, IHC, ICC, Neut
Validations
- (6)
Cat. No.
ABIN7193208
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC
Validations
- (6)
Cat. No.
ABIN1512715
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, IF, IHC
Validations
- (7)
Cat. No.
ABIN3030405
Quantity
0.4 mL
Datasheet
Datasheet
Recommended CD46 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6954523
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965590
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962394
Quantity
96 tests
Datasheet
Datasheet
Recommended CD46 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274180
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274175
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Dog
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274176
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CD46 products
: "The Role of Taste Receptor mTAS1R3 in Chemical Communication of Gametes." in: International journal of molecular sciences, Vol. 21, Issue 7, (2020) (PubMed).: "An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor." in: Cell, Vol. 174, Issue 5, pp. 1158-1171.e19, (2019) (PubMed).
: "Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions." in: Nature communications, Vol. 10, Issue 1, pp. 741, (2019) (PubMed).
: "CD46 facilitates entry and dissemination of human cytomegalovirus." in: Nature communications, Vol. 10, Issue 1, pp. 2699, (2019) (PubMed).
: "Alternative pathway activation due to low level of complement factor H in primary antiphospholipid syndrome." in: Thrombosis research, Vol. 164, pp. 63-68, (2018) (PubMed).
: "Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus." in: European journal of immunology, Vol. 47, Issue 7, pp. 1200-1210, (2017) (PubMed).
: "Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic." in: Molecular therapy. Methods & clinical development, Vol. 5, pp. 16013, (2016) (PubMed).
: "Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus." in: Cardiovascular diabetology, Vol. 15, Issue 1, pp. 152, (2016) (PubMed).
: "Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors." in: Journal of virology, Vol. 89, Issue 3, pp. 1512-22, (2015) (PubMed).
: "Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy." in: Molecular immunology, Vol. 65, Issue 2, pp. 302-9, (2015) (PubMed).
Synonyms and alternative names related to CD46
CD46 molecule (CD46), CD46 antigen, complement regulatory protein (Cd46), CD46 molecule (Cd46), CD46 molecule, complement regulatory protein (CD46), membrane cofactor protein-like (LOC100341359), membrane cofactor protein-like (LOC103789310), AHUS2, CD46, MCP, Mcp, MIC10, TLX, TRA2.10Protein level used designations for CD46
- CD46 antigen, complement regulatory protein
- antigen identified by monoclonal antibody TRA-2-10
- complement membrane cofactor protein
- measles virus receptor
- membrane cofactor protein
- membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
- trophoblast leucocyte common antigen
- trophoblast leukocyte common antigen
- trophoblast-lymphocyte cross-reactive antigen
- brain microvascular membrane cofactor
- membrane cofactor protein(GMP1-full)
- CD46 molecule
- Membrane cofactor protein
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