CD42b Products
(Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))
Categories
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq, Mar 2010].
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Featured CD42b Categories
CD42b Antibodies
High quality antibodies with extensive validation data.
CD42b ELISA Kits
Reliable ELISA kits for a wide range of species.
CD42b Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD42b Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA
Validations
- (5)
Cat. No.
ABIN5684108
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7440512
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, IP, ICC
Validations
- (2)
- (2)
Cat. No.
ABIN2752000
Quantity
0.1 mg
Datasheet
Datasheet
Recommended CD42b ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6973599
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960662
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882209
Quantity
96 tests
Datasheet
Datasheet
Recommended CD42b Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274755
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355499
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355497
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our CD42b products
: "GPIbα shedding in platelets is controlled by strict intracellular containment of both enzyme and substrate." in: Journal of thrombosis and haemostasis : JTH, (2023) (PubMed).: "Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice." in: Cell reports, Vol. 28, Issue 4, pp. 896-908.e5, (2019) (PubMed).
: "Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation." in: Haematologica, (2019) (PubMed).
: "Temperature effects on the activity, shape, and storage of platelets from 13-lined ground squirrels." in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, Vol. 187, Issue 5-6, pp. 815-825, (2017) (PubMed).
: "Nanoparticle biointerfacing by platelet membrane cloaking." in: Nature, Vol. 526, Issue 7571, pp. 118-21, (2015) (PubMed).
: "A dominant-negative GFI1B mutation in the gray platelet syndrome. ..." in: The New England journal of medicine, Vol. 370, Issue 3, pp. 245-53, (2014) (PubMed).
: "Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation." in: The Journal of experimental medicine, (2014) (PubMed).
: "Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse." in: Journal of thrombosis and haemostasis : JTH, Vol. 10, Issue 11, pp. 2344-53, (2014) (PubMed).
: "The collagen-binding integrin α2β1 is a novel interaction partner of the Trimeresurus flavoviridis venom protein flavocetin-A." in: The Journal of biological chemistry, Vol. 288, Issue 2, pp. 947-55, (2013) (PubMed).
: "Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case." in: Human pathology, Vol. 42, Issue 1, pp. 141-5, (2010) (PubMed).
Synonyms and alternative names related to CD42b
glycoprotein Ib platelet alpha subunit (GP1BA), glycoprotein Ib (platelet), alpha polypeptide (GP1BA), glycoprotein Ib platelet alpha subunit (Gp1ba), glycoprotein 1b, alpha polypeptide (Gp1ba), BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GP1BA, GPIbA, GPIba, GPIbalpha, VWDPProtein level used designations for CD42b
- GP-Ib alpha
- antigen CD42b-alpha
- platelet glycoprotein Ib alpha chain
- platelet membrane glycoprotein 1b-alpha subunit
- glycoprotein Ib (platelet), alpha polypeptide
- platelet glycoprotein Ib alpha polypeptide
- GPIb-alpha
- GPIbA
- glycoprotein Ibalpha
- glycoprotein 1b, alpha polypeptide
- platelet glycoprotein Ib alpha chain-like
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