CD40 Products
(CD40)
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Featured CD40 Categories
CD40 Antibodies
High quality antibodies with extensive validation data.
CD40 ELISA Kits
Reliable ELISA kits for a wide range of species.
CD40 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD40 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7442747
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, IHC, IF, StM, DNA Mic
Validations
- (5)
Cat. No.
ABIN6941185
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6260623
Quantity
100 μL
Datasheet
Datasheet
Recommended CD40 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954519
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954518
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954520
Quantity
96 tests
Datasheet
Datasheet
Recommended CD40 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
Cat. No.
ABIN7274186
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7274177
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274188
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CD40 products
: "Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist." in: Journal for immunotherapy of cancer, Vol. 9, Issue 1, (2021) (PubMed).: "Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line." in: BMC genomics, Vol. 20, Issue 1, pp. 15, (2019) (PubMed).
: "Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 12, pp. 4838-4847, (2017) (PubMed).
: "Pathogenic Phenotype of Adipogenesis and Hyaluronan in Orbital Fibroblasts From Female Graves' Orbitopathy Mouse Model." in: Endocrinology, Vol. 157, Issue 10, pp. 3771-3778, (2016) (PubMed).
: "Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy." in: Translational research : the journal of laboratory and clinical medicine, Vol. 166, Issue 3, pp. 281-91, (2015) (PubMed).
: "Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation." in: Angiology, Vol. 66, Issue 7, pp. 631-7, (2015) (PubMed).
: "Toll-like receptor-mediated responses by placental Hofbauer cells (HBCs): a potential pro-inflammatory role for fetal M2 macrophages." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 73, Issue 1, pp. 22-35, (2014) (PubMed).
: "A Short History of the B-Cell-Associated Surface Molecule CD40." in: Frontiers in immunology, Vol. 5, pp. 472, (2014) (PubMed).
: "Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guérin." in: European journal of immunology, Vol. 44, Issue 1, pp. 80-92, (2014) (PubMed).
: "The cell-to-cell coordination between activated T cells and CpG-stimulated macrophages synergistically induce elevated levels of IL-10 via NF-κB1, STAT3, and CD40/CD154." in: Cell communication and signaling : CCS, Vol. 11, pp. 95, (2014) (PubMed).
Synonyms and alternative names related to CD40
CD40 molecule (CD40), CD40 antigen (Cd40), CD40 molecule (Cd40), AI326936, Bp50, CDW40, GP39, HIGM1, IGM, IMD3, p50, T-BAM, TNFRSF5, Tnfrsf5, TNFSF5, TRAPProtein level used designations for CD40
- B cell surface antigen CD40
- B cell-associated molecule
- B-cell surface antigen CD40
- CD40 antigen (TNF receptor superfamily member 5)
- CD40 type II isoform
- CD40L receptor
- nerve growth factor receptor-related B-lymphocyte activation molecule
- tumor necrosis factor receptor superfamily member 5
- tumor necrosis factor receptor superfamily, member 5
- T-cell differentiation antigen
- human CD40-homologue
- CD40 antigen, TNF receptor superfamily member 5
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