CD35 Products
(Complement Component Receptor 1 (CD35) (CR1))
Categories
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008].
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Featured CD35 Categories
CD35 Antibodies
High quality antibodies with extensive validation data.
CD35 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended CD35 Antibodies
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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
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Cat. No.
ABIN7433177
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
IHC, IF
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- (4)
Cat. No.
ABIN7266477
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, ELISA
Validations
- (3)
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ABIN7148407
Quantity
100 μL
Datasheet
Datasheet
Recommended CD35 ELISA Kits
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Reactivity
Human
Analytical Method
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- (1)
Cat. No.
ABIN6955049
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6962520
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882188
Quantity
96 tests
Datasheet
Datasheet
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Reactivity
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Cat. No.
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Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393268
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3008960
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CD35 products
: "Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 2, pp. 3359-3366, (2020) (PubMed).: "FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 13, Issue 2, pp. 204-218, (2019) (PubMed).
: "Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease." in: Scientific reports, Vol. 8, Issue 1, pp. 526, (2018) (PubMed).
: "High complement levels in astrocyte-derived exosomes of Alzheimer disease." in: Annals of neurology, Vol. 83, Issue 3, pp. 544-552, (2018) (PubMed).
: "CEACAM1 mediates B cell aggregation in central nervous system autoimmunity." in: Scientific reports, Vol. 6, pp. 29847, (2016) (PubMed).
: "Susceptibility of human placenta derived mesenchymal stromal/stem cells to human herpesviruses infection." in: PLoS ONE, Vol. 8, Issue 8, pp. e71412, (2013) (PubMed).
: "Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 119, Issue 7, pp. 789-97, (2012) (PubMed).
: "Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 6, pp. 3064-77, (2012) (PubMed).
: "Attenuated, oncolytic, but not wild-type measles virus infection has pleiotropic effects on human neutrophil function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 3, pp. 1002-10, (2012) (PubMed).
: "Simultaneous quantitative analysis of the expression of CD64 and CD35 on neutrophils as markers to differentiate between bacterial and viral infections in patients with rheumatoid arthritis." in: Modern rheumatology, Vol. 22, Issue 5, pp. 750-7, (2012) (PubMed).
Synonyms and alternative names related to CD35
complement C3b/C4b receptor 1 (Knops blood group) (CR1), complement receptor 2 (Cr2), complement component (3d/Epstein Barr virus) receptor 2 (CR2), complement receptor type 1 (LOC718120), C3BR, C3DR, C4BR, CD21, CD35, Cr-1, Cr-2, Cr1, CR1, CR1-L, CR2, KNProtein level used designations for CD35
- C3-binding protein
- C3b/C4b receptor
- CD35 antigen
- Knops blood group antigen
- complement component receptor 1
- complement receptor type 1
- complement C3d receptor
- complement receptor type 2
- expressed in B lymphocytes
- LOW QUALITY PROTEIN: complement receptor type 1
- complement component (3b/4b) receptor 1 (Knops blood group)
- complement component (3d/Epstein Barr virus) receptor 2
- complement receptor type 1-like protein
- cr1 (CD35)
- complement receptor 1
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