CD1c Products
(T-cell surface glycoprotein CD1c (CD1C))
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This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008].
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Featured CD1c Categories
CD1c Antibodies
High quality antibodies with extensive validation data.
CD1c Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD1c Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, FACS, IHC, ICC, Neut
Validations
- (5)
Cat. No.
ABIN5611307
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, IHC, IP
Validations
- (4)
- (3)
Cat. No.
ABIN1981870
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
FACS
Validations
- (4)
Cat. No.
ABIN6240833
Quantity
100 tests
Datasheet
Datasheet
Recommended CD1c Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348558
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our CD1c products
: "Residual endotoxin contaminations in recombinant proteins are sufficient to activate human CD1c+ dendritic cells." in: PLoS ONE, Vol. 9, Issue 12, pp. e113840, (2014) (PubMed).: "The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation." in: Immunity, Vol. 33, Issue 6, pp. 853-62, (2010) (PubMed).
: "Membrane trafficking of CD1c on activated T cells." in: Journal of leukocyte biology, Vol. 70, Issue 4, pp. 567-77, (2001) (PubMed).
: "Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens." in: The Journal of experimental medicine, Vol. 192, Issue 2, pp. 281-8, (2000) (PubMed).
: "Increased numbers of dendritic cells in the bronchiolar tissues of diffuse panbronchiolitis." in: American journal of respiratory and critical care medicine, Vol. 162, Issue 1, pp. 148-53, (2000) (PubMed).
Synonyms and alternative names related to CD1c
CD1c molecule (CD1C), BDCA1, CD1, CD1A, R7Protein level used designations for CD1c
- CD1C antigen, c polypeptide
- T-cell surface glycoprotein CD1c
- cortical thymocyte antigen CD1C
- differentiation antigen CD1-alpha-3
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