CD130/gp130 Products
(Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
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The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010].
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Featured CD130/gp130 Categories
CD130/gp130 Antibodies
High quality antibodies with extensive validation data.
CD130/gp130 ELISA Kits
Reliable ELISA kits for a wide range of species.
CD130/gp130 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CD130/gp130 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7430552
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7430555
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (7)
Cat. No.
ABIN655059
Quantity
400 μL
Datasheet
Datasheet
Recommended CD130/gp130 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN366527
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970275
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962730
Quantity
96 tests
Datasheet
Datasheet
Recommended CD130/gp130 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307841
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7320393
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7196601
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CD130/gp130 products
: "Serum YKL-40 level is correlated with apnea hypopnea index in patients with obstructive sleep apnea sindrome." in: European review for medical and pharmacological sciences, Vol. 21, Issue 18, pp. 4161-4166, (2018) (PubMed).: "Granulocytes Are Unresponsive to IL-6 Due to an Absence of gp130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 10, pp. 3547-3555, (2018) (PubMed).
: "Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin." in: JCI insight, Vol. 3, Issue 14, (2018) (PubMed).
: "Interleukin‑6 induces an epithelial‑mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration." in: Molecular medicine reports, Vol. 15, Issue 6, pp. 4123-4131, (2018) (PubMed).
: "Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing." in: The American journal of pathology, Vol. 188, Issue 2, pp. 474-490, (2017) (PubMed).
: "Dendritic cell MST1 inhibits Th17 differentiation." in: Nature communications, Vol. 8, pp. 14275, (2017) (PubMed).
: "Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6trans-signaling." in: The Journal of biological chemistry, Vol. 292, Issue 16, pp. 6644-6656, (2017) (PubMed).
: "TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 10, pp. 4082-9, (2016) (PubMed).
: "Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies." in: Neurobiology of aging, Vol. 39, pp. 140-6, (2016) (PubMed).
: "Matrine increases NKG2D ligand ULBP2 in K562 cells via inhibiting JAK/STAT3 pathway: a potential mechanism underlying the immunotherapy of matrine in leukemia." in: American journal of translational research, Vol. 7, Issue 10, pp. 1838-49, (2015) (PubMed).
Synonyms and alternative names related to CD130/gp130
interleukin 6 signal transducer (IL6ST), interleukin 6 signal transducer (Il6st), interleukin 6 signal transducer (il6st), 5133400A03Rik, AA389424, Ac1055, BB405851, CD130, CDW130, D13Ertd699e, GP130, gp130, Gp130, IL-6, IL-6RB, Il-6rbProtein level used designations for CD130/gp130
- CD130 antigen
- IL-6 receptor subunit beta
- IL-6R subunit beta
- gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
- interleukin receptor beta chain
- interleukin-6 receptor subunit beta
- membrane glycoprotein 130
- membrane glycoprotein gp130
- oncostatin-M receptor subunit alpha
- IL-6R-beta
- IL-6RB
- interleukin-6 signal transducer
- interleukin 6 signal transducer
- glycoprotein 130
- LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta
- interleukin 6 signal transducer (gp130, oncostatin M receptor)
- interleukin 6 signal transducer receptor
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