CBX8 Products
(Chromobox Homolog 8 (CBX8))
Categories
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
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Featured CBX8 Categories
CBX8 Antibodies
High quality antibodies with extensive validation data.
CBX8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CBX8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (1)
- (4)
Cat. No.
ABIN1724766
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (1)
- (4)
Cat. No.
ABIN1724765
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN7147709
Quantity
100 μL
Datasheet
Datasheet
Recommended CBX8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348218
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3090750
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3130472
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CBX8 products
: "CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells." in: Biochemical and biophysical research communications, Vol. 469, Issue 4, pp. 884-90, (2016) (PubMed).: "Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor." in: The EMBO journal, Vol. 29, Issue 15, pp. 2553-65, (2010) (PubMed).
: "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus." in: The EMBO journal, Vol. 26, Issue 6, pp. 1637-48, (2007) (PubMed).
: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28785-92, (2000) (PubMed).
Synonyms and alternative names related to CBX8
chromobox 8 (cbx8), chromobox 8 (CBX8), chromobox 8 (Cbx8), chromobox 8 S homeolog (cbx8.S), chromobox homolog 8a (Pc class homolog, Drosophila) (cbx8a), cbx8, MGC147589, Pc3, PC3, RC1Protein level used designations for CBX8
- chromobox homolog 8
- chromobox protein homolog 8
- mPc3
- polycomb 3 homolog
- Pc class 3 homolog
- chromobox homolog 8 (Pc class homolog, Drosophila)
- polycomb 3
- rectachrome 1
- chromobox-like protein 8
- chromobox homolog 8 (Pc class homolog)
- chromobox homolog 8a
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