CBX4 Products
(Chromobox Homolog 4 (CBX4))
Categories
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
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Featured CBX4 Categories
CBX4 Antibodies
High quality antibodies with extensive validation data.
CBX4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CBX4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (6)
Cat. No.
ABIN5542423
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7150950
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (2)
- (2)
Cat. No.
ABIN389086
Quantity
400 μL
Datasheet
Datasheet
Recommended CBX4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6209563
Quantity
96 tests
Datasheet
Datasheet
Recommended CBX4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348212
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3091174
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131894
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CBX4 products
: "HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 253, Issue 8, pp. 1279-90, (2015) (PubMed).: "Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation." in: Cell death and differentiation, Vol. 21, Issue 7, pp. 1107-18, (2014) (PubMed).
: "Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos." in: Physiological genomics, Vol. 46, Issue 2, pp. 66-80, (2014) (PubMed).
: "CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage." in: Nucleic acids research, Vol. 40, Issue 12, pp. 5497-510, (2012) (PubMed).
: "Human Polycomb protein 2 promotes ?-synuclein aggregate formation through covalent SUMOylation." in: Brain research, Vol. 1381, pp. 78-89, (2011) (PubMed).
: "The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif." in: Molecular and cellular biology, Vol. 30, Issue 9, pp. 2193-205, (2010) (PubMed).
: "Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 43, pp. 16572-7, (2008) (PubMed).
: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).
: "The polycomb protein Pc2 is a SUMO E3." in: Cell, Vol. 113, Issue 1, pp. 127-37, (2003) (PubMed).
Synonyms and alternative names related to CBX4
chromobox 4 (CBX4), chromobox 4 (Cbx4), chromobox 4 S homeolog (cbx4.S), chromobox homolog 4 (CBX4), chromobox homolog 4 (Pc class homolog, Drosophila) (cbx4), cbx4-a, im:6911625, MPc2, NBP16, PC2, XPolycomb, zgc:158588Protein level used designations for CBX4
- chromobox homolog 4
- E3 SUMO-protein ligase CBX4
- chromobox protein homolog 4
- polycomb 2 homolog
- NS5ATP1-binding protein 16
- Pc class 2 homolog
- chromobox homolog 4 (Pc class homolog, Drosophila)
- chromobox homolog 4 (Pc class homolog)
- chromobox homolog 4 (Polycomb)
- chromobox protein (CHCB3)
- chromobox-like protein 4
- polycomb 2
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