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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (GST tag) (ABIN1348172)

CBLB Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag) (ABIN7122186)

CBLB Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 21-129) protein (GST tag) (ABIN1348174)

CBLB Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Origin

Find Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins for a variety of species such as anti-Human Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase, anti-Mouse Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase. The species listed below are among those available. Click on a link to go to the corresponding products.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Source

Here you will find Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Protein Type

Here you can find Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Application

Find Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins validated for a specific application such as ELISA, WB, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1348172

Quantity 10 μg

Datasheet Datasheet

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7122186

Quantity 50 μg

Datasheet Datasheet

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 21-129) protein (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1348174

Quantity 10 μg

Datasheet Datasheet

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3090503

Quantity 1 mg

Datasheet Datasheet

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-982) protein (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134985

Quantity 1 mg

Datasheet Datasheet

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) protein (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2713255

Quantity 20 μg

Datasheet Datasheet

Latest Publications for our Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

Gruber, Hinterleitner, Hermann-Kleiter, Meisel, Kleiter, Wang, Viola, Pfeifhofer-Obermair, Baier: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." in: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).

Aliases for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S) Proteins
Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L) Proteins
Casitas B-lineage lymphoma b (Cblb) Proteins
Cbl proto-oncogene B (Cblb) Proteins
Cbl proto-oncogene B (CBLB) Proteins
AI429560 Proteins
AI851073 Proteins
Cbl-b Proteins
cblb Proteins
rnf56 Proteins

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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Origin

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Source

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Protein Type

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins by Application

Popular Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

Latest Publications for our Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

Aliases for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins

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