Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Products
(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
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E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.
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Featured Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Categories
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Antibodies
High quality antibodies with extensive validation data.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits
Reliable ELISA kits for a wide range of species.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN652612
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN760256
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN6260515
Quantity
100 μL
Datasheet
Datasheet
Recommended Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965529
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1131076
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6200984
Quantity
96 tests
Datasheet
Datasheet
Recommended Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1348172
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122186
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348174
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase products
: "Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b)." in: The Journal of biological chemistry, Vol. 290, Issue 42, pp. 25595-608, (2015) (PubMed).: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." in: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).
: "The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 14, pp. 6459-64, (2010) (PubMed).
Synonyms and alternative names related to Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S), Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L), Casitas B-lineage lymphoma b (Cblb), Cbl proto-oncogene B (Cblb), Cbl proto-oncogene B (CBLB), AI429560, AI851073, Cbl-b, cblb, rnf56Protein level used designations for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b
- Cbl proto-oncogene, E3 ubiquitin protein ligase B
- E3 ubiquitin-protein ligase CBL-B-B
- SH3-binding protein CBL-B-B
- signal transduction protein CBL-B-B
- E3 ubiquitin-protein ligase CBL-B-A
- SH3-binding protein CBL-B-A
- signal transduction protein CBL-B-A
- Casitas B-lineage lymphoma proto-oncogene b
- E3 ubiquitin-protein ligase CBL-B
- RING-type E3 ubiquitin transferase CBL-B
- SH3-binding protein CBL-B
- Signal transduction protein CBL-B
- casitas B-lineage lymphoma proto-oncogene b
- signal transduction protein CBL-B
- Cas-Br-M (murine) ectropic retroviral transforming sequence b
- Casitas B-lineage lymphoma b
- Cbl proto-oncogene B, E3 ubiquitin protein ligase
- LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B
- Cas-Br-M ecotropic retroviral transforming sequence b
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