CBFB Products
(Core-Binding Factor, beta Subunit (CBFB))
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The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit\; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured CBFB Categories
CBFB Antibodies
High quality antibodies with extensive validation data.
CBFB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CBFB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7444325
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p), FACS
Validations
- (5)
Cat. No.
ABIN390892
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, ChIP
Validations
- (6)
Cat. No.
ABIN6655308
Quantity
100 μL
Datasheet
Datasheet
Recommended CBFB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951394
Quantity
96 tests
Datasheet
Datasheet
Recommended CBFB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348166
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348164
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2128359
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CBFB products
: "Functions of Smad Transcription Factors in TGF-β1-Induced Selectin Ligand Expression on Murine CD4 Th Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 7, pp. 2627-34, (2016) (PubMed).Synonyms and alternative names related to CBFB
core-binding factor beta subunit (CBFB), core binding factor beta subunit (Cbfb), core-binding factor, beta subunit (cbfb), core-binding factor, beta subunit (Cbfb), core-binding factor, beta subunit S homeolog (cbfb.S), core binding factor beta (Cbfb), core-binding factor beta subunit (Cbfb), AI893578, cbf-beta, Cbfb, CBFB, cbfbeta, PEA2, pea2-beta, Pebp2, pebp2-beta, PEBP2B, pebp2b, PEBP2b, Pebpb2, unp1266Protein level used designations for CBFB
- CBF-beta
- PEA2-beta
- PEBP2-beta
- SL3-3 enhancer factor 1 beta subunit
- SL3-3 enhancer factor 1 subunit beta
- SL3/AKV core-binding factor beta subunit
- core-binding factor subunit beta
- polyomavirus enhancer binding protein 2, beta subunit
- polyomavirus enhancer-binding protein 2 beta subunit
- core binding factor beta subunit
- core-binding factor, beta subunit
- core binding factor beta
- core-binding factor beta
- CCAAT-binding transcription factor subunit B
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