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C6 Products

(Complement Component 6 (C6))
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012].

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Featured C6 Categories

C6 Antibodies

High quality antibodies with extensive validation data.

C6 ELISA Kits

Reliable ELISA kits for a wide range of species.

C6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended C6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7435277
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IF, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN390924
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, FACS, IF
Validations
  • (7)
Cat. No. ABIN3029693
Quantity 0.4 mL
Datasheet Datasheet

Recommended C6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966018
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955020
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1440229
Quantity 96 tests
Datasheet Datasheet

Recommended C6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1776082
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7198986
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7397030
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our C6 products

Bettoni, Galbusera, Gastoldi, Donadelli, Tentori, Spartà, Bresin, Mele, Alberti, Tortajada, Yebenes, Remuzzi, Noris: "Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 199, Issue 3, pp. 1021-1040, (2017) (PubMed).

Zhang, Li, Shan, Wang, Qiu, Lu, Zhao, Zhu, He, Wang: "Sublytic C5b-9 induces IL-6 and TGF-?1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBP? acetylation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 3, pp. 1511-25, (2014) (PubMed).

Orren: "Molecular mechanisms of complement component C6 deficiency; a hypervariable exon 6 region responsible for three of six reported defects." in: Clinical and experimental immunology, Vol. 119, Issue 2, pp. 255-8, (2000) (PubMed).

Zhu, Atkinson, Hovanky, Boppana, Dai, Densen, Go, Jablecki, Volanakis: "High prevalence of complement component C6 deficiency among African-Americans in the south-eastern USA." in: Clinical and experimental immunology, Vol. 119, Issue 2, pp. 305-10, (2000) (PubMed).

Sato, Van Dixhoorn, Prins, Mooney, Verhagen, Muizert, Savill, Van Es, Daha: "The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosis." in: Journal of the American Society of Nephrology : JASN, Vol. 10, Issue 6, pp. 1242-52, (1999) (PubMed).

Baker, Ochi, Schulze, Johnson, Campbell, Couser: "Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats." in: The American journal of pathology, Vol. 135, Issue 1, pp. 185-94, (1989) (PubMed).

Schulze, Baker, Perkinson, Johnson, Ochi, Stahl, Couser: "Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis in the rat." in: Kidney international, Vol. 35, Issue 1, pp. 60-8, (1989) (PubMed).

Synonyms and alternative names related to C6

complement component 6 (c6), complement C6 (C6), complement component 6, gene 1 L homeolog (c6.1.L), complement component 6, gene 2 (c6.2), complement component 6 (C6), AW111623, c6, C6, MGC82168, MGC89471, zgc:64073

Protein level used designations for C6

  • complement component C6
  • sixth complement component
  • complement component 6
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