C5A Products
(Complement Component 5a (C5a))
Categories
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008].
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Featured C5A Categories
C5A Antibodies
High quality antibodies with extensive validation data.
C5A ELISA Kits
Reliable ELISA kits for a wide range of species.
C5A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended C5A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (9)
Cat. No.
ABIN7442321
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7427906
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC (p)
Validations
- (6)
Cat. No.
ABIN3029692
Quantity
100 μg
Datasheet
Datasheet
Recommended C5A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
- (1)
Cat. No.
ABIN6955014
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6955015
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6962855
Quantity
96 tests
Datasheet
Datasheet
Recommended C5A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7274012
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122470
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN2180666
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our C5A products
: "C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis." in: Frontiers in immunology, Vol. 10, pp. 1866, (2020) (PubMed).: "C5aR deficiency attenuates the breast cancer development via the p38/p21 axis." in: Aging, Vol. 12, Issue 14, pp. 14285-14299, (2020) (PubMed).
: "Inhibition of osteoclast activity by complement regulation with DF3016A, a novel small-molecular-weight C5aR inhibitor." in: Biomedicine & pharmacotherapy, Vol. 123, pp. 109764, (2020) (PubMed).
: "Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression." in: Cancer letters, Vol. 412, pp. 30-36, (2017) (PubMed).
: "Complement Split Products C3a/C5a and Receptors: Are They Regulated by Circulating Angiotensin II Type 1 Receptor Autoantibody in Severe Preeclampsia?" in: Gynecologic and obstetric investigation, Vol. 81, Issue 1, pp. 28-33, (2016) (PubMed).
: "Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery." in: International immunopharmacology, Vol. 32, pp. 66-75, (2016) (PubMed).
: "Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis." in: Journal of neuroimmunology, Vol. 295-296, pp. 130-8, (2016) (PubMed).
: "Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia." in: Environmental pollution (Barking, Essex : 1987), Vol. 218, pp. 770-782, (2016) (PubMed).
: "Nanofibrous heparin and heparin-mimicking multilayers as highly effective endothelialization and antithrombogenic coatings." in: Biomacromolecules, Vol. 16, Issue 3, pp. 992-1001, (2015) (PubMed).
: "Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice." in: Toxicology and applied pharmacology, Vol. 287, Issue 1, pp. 86-92, (2015) (PubMed).
Synonyms and alternative names related to C5A
complement C5 (C5), C5a, C5b, CPAMD4, Hc, RGD1561905Protein level used designations for C5A
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
- C5a anaphylatoxin
- anaphylatoxin C5a analog
- complement C5
- prepro-C5
- anaphylatoxin
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