C4B Products
(Complement Component C4b (C4b))
Categories
This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008].
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Featured C4B Categories
C4B Antibodies
High quality antibodies with extensive validation data.
C4B ELISA Kits
Reliable ELISA kits for a wide range of species.
C4B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended C4B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433423
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7433420
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN513870
Quantity
100 μg
Datasheet
Datasheet
Recommended C4B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955023
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962759
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955024
Quantity
96 tests
Datasheet
Datasheet
Recommended C4B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122473
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347538
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347540
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our C4B products
: "Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration." in: Experimental eye research, Vol. 172, pp. 21-29, (2018) (PubMed).: "Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 12, Issue 6, pp. 1409-18, (2012) (PubMed).
: "Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 11, pp. 2605-14, (2007) (PubMed).
: "Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 1, pp. 128-37, (2005) (PubMed).
: "Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5489-95, (2002) (PubMed).
: "Anti-DNA autoreactivity in C4-deficient mice." in: European journal of immunology, Vol. 32, Issue 9, pp. 2672-9, (2002) (PubMed).
: "Monoclonal antibodies to complement components without the need of their prior purification. II. Antibodies to mouse C3 and C4." in: Hybridoma, Vol. 9, Issue 4, pp. 309-17, (1990) (PubMed).
Synonyms and alternative names related to C4B
complement C4B (Chido blood group) (C4B), complement C4A (Rodgers blood group) (C4A), complement component 4 (c4), complement C4-B (LOC462577), complement component 4B (Chido blood group) (C4B), complement component 4A (Rodgers blood group) (C4a), complement component 4B (Chido blood group) (C4b), complement C4B (Chido blood group) (C4b), C4, C4-2, C4A2, C4A3, C4A4, C4A6, C4AD, C4B, C4B1, C4B2, C4B3, C4B5, C4B12, C4BD, C4B_2, C4F, C4l, C4S, CH, CO4, CPAMD2, CPAMD3, DKFZP469I0332, RG, Slp, Ss, wu:fi14a03Protein level used designations for C4B
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
- Chido form of C4
- basic complement C4
- complement C4-B
- complement C4B1a
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
- C4A anaphylatoxin
- Rodgers form of C4
- acidic C4
- acidic complement C4
- complement C4-A
- complement component 4A
- complement component 4B
- complement component 4B (Chido blood group)
- sex-limited protein
- complement component 4 (within H-2S)
- complement component 4B (Childo blood group)
- complement C4-like protein
- complement component 4, gene 2
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