Cathepsin B Products
(Cathepsin B (CTSB))
Categories
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured Cathepsin B Categories
Cathepsin B Antibodies
High quality antibodies with extensive validation data.
Cathepsin B ELISA Kits
Reliable ELISA kits for a wide range of species.
Cathepsin B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Cathepsin B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (8)
Cat. No.
ABIN3021176
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (5)
Cat. No.
ABIN7146996
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, ICC, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (4)
Cat. No.
ABIN687412
Quantity
100 μL
Datasheet
Datasheet
Recommended Cathepsin B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962721
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954447
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954448
Quantity
96 tests
Datasheet
Datasheet
Recommended Cathepsin B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350702
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350704
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN2752768
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Cathepsin B products
: "Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients." in: Endocrine, Vol. 57, Issue 1, pp. 148-155, (2018) (PubMed).: "Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses." in: ACS infectious diseases, Vol. 4, Issue 8, pp. 1235-1245, (2018) (PubMed).
: "Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage ..." in: Autophagy, Vol. 12, Issue 9, pp. 1593-613, (2017) (PubMed).
: "Cysteine protease cathepsin B mediates radiation-induced bystander effects." in: Nature, Vol. 547, Issue 7664, pp. 458-462, (2017) (PubMed).
: "Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy." in: Nature cell biology, Vol. 18, Issue 8, pp. 851-63, (2016) (PubMed).
: "Urinary proteins induce lysosomal membrane permeabilization and lysosomal dysfunction in renal tubular epithelial cells." in: American journal of physiology. Renal physiology, Vol. 308, Issue 6, pp. F639-49, (2015) (PubMed).
: "Cathepsin B in human myometrium and in uterine leiomyomas at various stages of tumour growth." in: European journal of obstetrics, gynecology, and reproductive biology, Vol. 185, pp. 140-4, (2015) (PubMed).
: "Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting." in: Scientific reports, Vol. 5, pp. 13476, (2015) (PubMed).
: "Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats." in: Neural regeneration research, Vol. 9, Issue 13, pp. 1288-96, (2014) (PubMed).
: "?-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages." in: The Journal of biological chemistry, Vol. 289, Issue 46, pp. 31891-904, (2014) (PubMed).
Synonyms and alternative names related to Cathepsin B
cathepsin B (CTSB), cathepsin B (Ctsb), cathepsin B S homeolog (ctsb.S), cathepsin B (LOC692390), APPS, apps, CB, CPSB, cpsb, CTSB, LOC692390Protein level used designations for Cathepsin B
- APP secretase
- amyloid precursor protein secretase
- cathepsin B1
- cysteine protease
- RSG-2
- BCSB
- cathepsin B
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