Catechol-O-Methyltransferase Products
(Catechol-O-Methyltransferase (COMT))
Categories
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008].
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Featured Catechol-O-Methyltransferase Categories
Catechol-O-Methyltransferase Antibodies
High quality antibodies with extensive validation data.
Catechol-O-Methyltransferase ELISA Kits
Reliable ELISA kits for a wide range of species.
Catechol-O-Methyltransferase Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Catechol-O-Methyltransferase Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (6)
Cat. No.
ABIN185682
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN185328
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN2854980
Quantity
100 μL
Datasheet
Datasheet
Recommended Catechol-O-Methyltransferase ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954432
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954433
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954434
Quantity
96 tests
Datasheet
Datasheet
Recommended Catechol-O-Methyltransferase Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122177
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350032
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666744
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Catechol-O-Methyltransferase products
: "m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 165, Issue 2, pp. 431-446, (2018) (PubMed).: "Inhibitory Effect of Bovine Lactoferrin on Catechol-O-Methyltransferase." in: Molecules (Basel, Switzerland), Vol. 22, Issue 8, (2018) (PubMed).
: "Activation of the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism by 2,2',4,4'-tetrabromodiphenyl ether (BDE47) in the pig ovary." in: Reproductive toxicology (Elmsford, N.Y.), Vol. 34, Issue 3, pp. 436-42, (2012) (PubMed).
: "Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury." in: American journal of physiology. Renal physiology, Vol. 302, Issue 6, pp. F742-9, (2012) (PubMed).
: "Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT." in: Molecular and cellular endocrinology, Vol. 331, Issue 1, pp. 158-67, (2010) (PubMed).
: "Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes." in: Organic letters, Vol. 12, Issue 10, pp. 2414-7, (2010) (PubMed).
: "Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults." in: Neurobiology of learning and memory, Vol. 94, Issue 3, pp. 364-72, (2010) (PubMed).
: "Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17α in preeclampsia." in: Pharmacogenetics and genomics, Vol. 20, Issue 10, pp. 605-10, (2010) (PubMed).
: "Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism." in: Comprehensive psychiatry, Vol. 51, Issue 5, pp. 510-5, (2010) (PubMed).
: "Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT." in: Sleep, Vol. 33, Issue 8, pp. 1027-35, (2010) (PubMed).
Synonyms and alternative names related to Catechol-O-Methyltransferase
catechol-O-methyltransferase (COMT), catechol-O-methyltransferase (Comt), microRNA 4761 (MIR4761), catechol-O-methyltransferase (comt), catechol-O-methyltransferase (comt.2), catechol-O-methyltransferase S homeolog (comt.S), methyltransferase (Rv1703c), catechol-o-methyltransferase (Mb1729c), catechol-O-methyltransferase a (comta), catechol-O-methyltransferase b (comtb), catechol O-methyltransferase (LOC100354142), COMT, comt, Comt1, D16Wsu103e, D330014B15Rik, mb-comt, MGC154444, s-comt, si:dkey-13a21.15, zgc:114157, zgc:162236, zK13A21.15Protein level used designations for Catechol-O-Methyltransferase
- catechol O-methyltransferase
- catechol-O-methyltransferase 1
- catecholamine-O-methyltransferase
- catechol-O-methyltransferase
- O-methyltransferase
- catechol-o-methyltransferase
- catechol O-methyltransferase, soluble form
- catechol O-methyltransferase, membrane-bound form
- catechol-O-methyltransferase a
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