Caspase-8 p18 Products
(Caspase 8 Subunit P18)
Categories
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008].
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Recommended Caspase-8 p18 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN3188085
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN6281720
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
Cat. No.
ABIN7302572
Quantity
100 μL
Datasheet
Datasheet
Synonyms and alternative names related to Caspase-8 p18
caspase 8 (CASP8), caspase 8 (Casp8), ALPS2B, CAP4, Casp-8, CASP-8, FLICE, MACH, MCH5, Mch5Protein level used designations for Caspase-8 p18
- FADD-homologous ICE/CED-3-like protease
- FADD-like ICE
- ICE-like apoptotic protease 5
- MACH-alpha-1/2/3 protein
- MACH-beta-1/2/3/4 protein
- MORT1-associated ced-3 homolog
- apoptotic cysteine protease
- apoptotic protease Mch-5
- caspase 8, apoptosis-related cysteine protease
- caspase-8
- Fas-linked ICE-like protease
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