Caspase 8 Products
(Caspase 8 (CASP8))
Categories
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008].
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Featured Caspase 8 Categories
Caspase 8 Antibodies
High quality antibodies with extensive validation data.
Caspase 8 ELISA Kits
Reliable ELISA kits for a wide range of species.
Caspase 8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Caspase 8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Monkey, Mouse, Pig, Rat, Sheep
Application
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
- (15)
- (5)
- (1)
Cat. No.
ABIN724205
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (17)
- (12)
Cat. No.
ABIN6137970
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (10)
Cat. No.
ABIN7444115
Quantity
100 μL
Datasheet
Datasheet
Recommended Caspase 8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
Cat. No.
ABIN6574227
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
Cat. No.
ABIN6730951
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6954426
Quantity
96 tests
Datasheet
Datasheet
Recommended Caspase 8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122169
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122170
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505388
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Caspase 8 products
: "Tranilast attenuates methotrexate-induced renal and hepatic toxicities: Role of apoptosis-induced tissue proliferation." in: Journal of biochemical and molecular toxicology, Vol. 34, Issue 5, pp. e22466, (2021) (PubMed).: "NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma." in: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 26, (2020) (PubMed).
: "The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis." in: Experimental cell research, Vol. 382, Issue 1, pp. 111467, (2020) (PubMed).
: "Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells." in: The international journal of biochemistry & cell biology, Vol. 122, pp. 105731, (2020) (PubMed).
: "Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis." in: Redox biology, Vol. 29, pp. 101392, (2020) (PubMed).
: "Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway." in: Investigational new drugs, Vol. 38, Issue 1, pp. 50-59, (2020) (PubMed).
: "Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke." in: Cell death & disease, Vol. 10, Issue 7, pp. 487, (2020) (PubMed).
: "GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis." in: Free radical biology & medicine, Vol. 145, pp. 237-249, (2020) (PubMed).
: "Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway." in: International journal of molecular sciences, Vol. 20, Issue 19, (2020) (PubMed).
: "Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis." in: Carcinogenesis, Vol. 41, Issue 5, pp. 678-688, (2020) (PubMed).
Synonyms and alternative names related to Caspase 8
caspase 8 L homeolog (casp8.L), death related ced-3/Nedd2-like protein (LOC661095), caspase 8 (CASP8), caspase-8 (LOC5563818), caspase-8 (casp8), caspase-8-like (LOC100222284), caspase 8 (Casp8), caspase 8, apoptosis-related cysteine peptidase (casp8), ALPS2B, CAP4, CASP-8, Casp-8, casp8, CASP8, casp8-A, caspase-8, FLICE, MACH, Mch5, MCH5, xCaspase-8, zgc:92075Protein level used designations for Caspase 8
- caspase-8
- xcaspase 8
- death related ced-3/Nedd2-like protein
- GLEAN_14026
- caspase 8, apoptosis-related cysteine peptidase
- caspase 8
- caspase-8-like
- DEATH effector domain caspase
- Fas-linked ICE-like protease
- FADD-homologous ICE/CED-3-like protease
- FADD-like ICE
- ICE-like apoptotic protease 5
- MACH-alpha-1/2/3 protein
- MACH-beta-1/2/3/4 protein
- MORT1-associated ced-3 homolog
- apoptotic cysteine protease
- apoptotic protease Mch-5
- caspase 8, apoptosis-related cysteine protease
- caspase-8a
- cysteine protease
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