Caspase 4 Products
(Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
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This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
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Featured Caspase 4 Categories
Caspase 4 Antibodies
High quality antibodies with extensive validation data.
Caspase 4 ELISA Kits
Reliable ELISA kits for a wide range of species.
Caspase 4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Caspase 4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
Cat. No.
ABIN1326998
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (3)
Cat. No.
ABIN7438061
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (3)
Cat. No.
ABIN7146946
Quantity
100 μg
Datasheet
Datasheet
Recommended Caspase 4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954420
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965468
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965467
Quantity
96 tests
Datasheet
Datasheet
Recommended Caspase 4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122167
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348107
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394738
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Caspase 4 products
: "Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D." in: Mucosal immunology, Vol. 12, Issue 2, pp. 323-339, (2019) (PubMed).: "Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis." in: Cell reports, Vol. 26, Issue 6, pp. 1614-1626.e5, (2019) (PubMed).
: "Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury." in: Frontiers in molecular neuroscience, Vol. 12, pp. 36, (2019) (PubMed).
: "E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation." in: Cell death and differentiation, (2019) (PubMed).
: "IRF2 transcriptionally induces GSDMD expression for pyroptosis." in: Science signaling, Vol. 12, Issue 582, (2019) (PubMed).
: "Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis." in: The Journal of experimental medicine, Vol. 216, Issue 11, pp. 2562-2581, (2019) (PubMed).
: "Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration." in: Frontiers in immunology, Vol. 9, pp. 2015, (2019) (PubMed).
: "Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-κB, MAPK and NLRP3 inflammasome signaling pathways." in: The Journal of nutritional biochemistry, Vol. 74, pp. 108229, (2019) (PubMed).
: "Obesity-associated NLRC4 inflammasome activation drives breast cancer progression." in: Nature communications, Vol. 7, pp. 13007, (2018) (PubMed).
: "Copper Regulates the Canonical NLRP3 Inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 5, pp. 1607-1617, (2018) (PubMed).
Synonyms and alternative names related to Caspase 4
caspase 4 (CASP4), caspase 4 (Casp4), caspase 4, apoptosis-related cysteine peptidase (CASP4), caspase 4, apoptosis-related cysteine peptidase (Casp4), caspase-4 (LOC100731032), CASP1, CASP4, Casp4, Casp11, CASP13, Caspl, ICE(rel)II, ICEREL-II, ICH-2, ich-3, Mih1/TX, TXProtein level used designations for Caspase 4
- CASP-4
- ICE(rel)-II
- apoptotic cysteine protease Mih1/TX
- caspase 4, apoptosis-related cysteine protease
- caspase-4
- protease ICH-2
- protease TX
- caspase 11
- caspase 4
- CASP-13
- ERICE
- caspase 13
- caspase-13
- evolutionary related interleukin-1-beta-converting enzyme
- CASP-1
- ICE
- IL-1 beta-converting enzyme
- IL-1BC
- caspase-1
- caspase-1/caspase-4 hybrid
- interleukin-1 beta convertase
- interleukin-1 beta-converting enzyme
- p45
- CASP-11
- caspase 11, apoptosis-related cysteine peptidase
- caspase 11, apoptosis-related cysteine protease
- caspase-11 short form splicing
- protease ICH-3
- caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
- caspase 4, apoptosis-related cysteine peptidase
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