Caspase 12 (Gene/pseudogene) Products
(Caspase 12 (Gene/pseudogene) (CASP12))
Categories
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].
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Featured Caspase 12 (Gene/pseudogene) Categories
Caspase 12 (Gene/pseudogene) Antibodies
High quality antibodies with extensive validation data.
Caspase 12 (Gene/pseudogene) ELISA Kits
Reliable ELISA kits for a wide range of species.
Caspase 12 (Gene/pseudogene) Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Caspase 12 (Gene/pseudogene) Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (10)
Cat. No.
ABIN7442993
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7440263
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (8)
- (5)
Cat. No.
ABIN737736
Quantity
100 μL
Datasheet
Datasheet
Recommended Caspase 12 (Gene/pseudogene) ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965454
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965453
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965452
Quantity
96 tests
Datasheet
Datasheet
Recommended Caspase 12 (Gene/pseudogene) Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7415872
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7422757
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7406635
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Caspase 12 (Gene/pseudogene) products
: "Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD." in: Life sciences, Vol. 209, pp. 455-465, (2018) (PubMed).: "Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes." in: PLoS ONE, Vol. 12, Issue 4, pp. e0173469, (2017) (PubMed).
: "Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 39, Issue 1, pp. 123-36, (2016) (PubMed).
: "Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways." in: Heart and vessels, (2016) (PubMed).
: "Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: A mechanistic study." in: Biochemical pharmacology, Vol. 95, Issue 3, pp. 145-55, (2015) (PubMed).
: "Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen ..." in: International journal of molecular medicine, Vol. 36, Issue 1, pp. 43-52, (2015) (PubMed).
: "Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis." in: International journal of clinical and experimental pathology, Vol. 8, Issue 8, pp. 9256-63, (2015) (PubMed).
: "Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome." in: Gene, Vol. 545, Issue 1, pp. 156-62, (2014) (PubMed).
: "Zinc chloride inhibits human lens epithelial cell migration and proliferation involved in TGF-β1 and TNF-α signaling pathways in HLE B-3 cells." in: Biological trace element research, Vol. 159, Issue 1-3, pp. 425-33, (2014) (PubMed).
: "Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells." in: PLoS ONE, Vol. 9, Issue 12, pp. e115204, (2014) (PubMed).
Synonyms and alternative names related to Caspase 12 (Gene/pseudogene)
caspase 12 (Casp12), caspase 12 (CASP12), caspase 12 (gene/pseudogene) (CASP12), CASP-12, CASP12P1, Caspase-12Protein level used designations for Caspase 12 (Gene/pseudogene)
- CASP-12
- caspase-12
- caspase 12 pseudogene 1
- inactive caspase-12
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