CASC5 Products
(Cancer Susceptibility Candidate 5 (CASC5))
Categories
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11\;15)(q23\;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013].
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Featured CASC5 Categories
CASC5 Antibodies
High quality antibodies with extensive validation data.
CASC5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CASC5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7256628
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN6137952
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
Cat. No.
ABIN760391
Quantity
100 μL
Datasheet
Datasheet
Recommended CASC5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348085
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7420573
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7423420
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CASC5 products
: "Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment." in: Scientific reports, Vol. 8, Issue 1, pp. 3888, (2019) (PubMed).: "TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment." in: The Journal of cell biology, Vol. 209, Issue 2, pp. 221-34, (2015) (PubMed).
: "ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments." in: Oncotarget, Vol. 6, Issue 39, pp. 41550-65, (2015) (PubMed).
Synonyms and alternative names related to CASC5
kinetochore scaffold 1 (KNL1), kinetochore scaffold 1 (Knl1), Kinetochore null protein 1 (knl-1), 2310043D08Rik, 5730505K17Rik, AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Rad51, Spc7Protein level used designations for CASC5
- cancer susceptibility candidate 5
- ALL1-fused gene from chromosome 15q14 protein
- blinkin, bub-linking kinetochore protein
- cancer susceptibility candidate gene 5 protein
- cancer/testis antigen 29
- kinetochore null 1 homolog
- kinetochore-null protein 1
- protein CASC5
- protein phosphatase 1, regulatory subunit 55
- RAD51 homolog
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