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CARD16 Products

(Caspase Recruitment Domain Family, Member 16 (CARD16))

Categories

Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

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Featured CARD16 Categories

CARD16 Antibodies

High quality antibodies with extensive validation data.

CARD16 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CARD16 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (2)
Cat. No. ABIN7244684
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN530261
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN566717
Quantity 100 μg
Datasheet Datasheet

Recommended CARD16 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348045
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3090483
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2713162
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our CARD16 products

Druilhe, Srinivasula, Razmara, Ahmad, Alnemri: "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins." in: Cell death and differentiation, Vol. 8, Issue 6, pp. 649-57, (2001) (PubMed).

Synonyms and alternative names related to CARD16

caspase recruitment domain family member 16 (CARD16), COP, COP1, PSEUDO-ICE

Protein level used designations for CARD16

  • CARD only domain-containing protein 1
  • CARD only protein
  • caspase recruitment domain-containing protein 16
  • caspase-1 dominant-negative inhibitor pseudo-ICE
  • caspase-1 inhibitor COP
  • pseudo interleukin-1 beta converting enzyme
  • pseudo interleukin-1beta converting enzyme
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