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Carboxy Methyl Lysine Products

(Carboxy Methyl Lysine (CML))
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured Carboxy Methyl Lysine Categories

Carboxy Methyl Lysine Antibodies

High quality antibodies with extensive validation data.

Carboxy Methyl Lysine ELISA Kits

Reliable ELISA kits for a wide range of species.

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Latest Publications for our Carboxy Methyl Lysine products

Zhao, Liu, Ten, Zhang, Yuan, Yu, An: "Plasma heparanase is associated with blood glucose levels but not urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage." in: Renal failure, Vol. 39, Issue 1, pp. 698-701, (2018) (PubMed).

Liu, Wang, Qi, Zou, Sun: "Antiglycation and antioxidant activities of mogroside extract from Siraitia grosvenorii (Swingle) fruits." in: Journal of food science and technology, Vol. 55, Issue 5, pp. 1880-1888, (2018) (PubMed).

Svrckova, Zatloukalova, Dvorakova, Coufalova, Novak, Hernychova, Vacek: "Na(+)/K(+)-ATPase interaction with methylglyoxal as reactive metabolic side product." in: Free radical biology & medicine, Vol. 108, pp. 146-154, (2017) (PubMed).

Cannizzaro, Rossoni, Savi, Altomare, Marinello, Saethang, Carini, Payne, Pisitkun, Aldini, Leelahavanichkul: "Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome." in: Nutrition & metabolism, Vol. 14, pp. 5, (2017) (PubMed).

Di Pino, Currenti, Urbano, Scicali, Piro, Purrello, Rabuazzo: "High intake of dietary advanced glycation end-products is associated with increased arterial stiffness and inflammation in subjects with type 2 diabetes." in: Nutrition, metabolism, and cardiovascular diseases : NMCD, Vol. 27, Issue 11, pp. 978-984, (2017) (PubMed).

Martins, Oliveira, Vizcaíno, Fonseca, Gouveia, Silva, Henriques, Noronha, Rodrigues: "Advanced Glycation End Products Evolution after Pancreas-Kidney Transplantation: Plasmatic and Cutaneous Assessments." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 2189582, (2016) (PubMed).

Fang, Wang, Li, Guo et al.: "Advanced glycation end-products accelerate the cardiac aging process through the receptor for advanced glycation end-products/transforming growth factor-β-Smad signaling pathway in cardiac ..." in: Geriatrics & gerontology international, Vol. 16, Issue 4, pp. 522-7, (2016) (PubMed).

Liebisch, Bondeva, Franke, Hause, Wolf: "Growth arrest specific 2-like protein 1 expression is upregulated in podocytes through advanced glycation end-products." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, (2016) (PubMed).

Mishra, Saxena, Shukla, Singh, Meyer, Kruzliak, Khanna: "Association of serum N(ε)-Carboxy methyl lysine with severity of diabetic retinopathy." in: Journal of diabetes and its complications, Vol. 30, Issue 3, pp. 511-7, (2016) (PubMed).

Mishra, Saxena, Ruia, Prasad, Singh, Khanna, Staffa, Gaspar, Kruzliak: "Increased levels of N(ε)- Carboxy methyl lysine (N(ε)-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study." in: Journal of diabetes and its complications, Vol. 30, Issue 5, pp. 868-72, (2016) (PubMed).

Synonyms and alternative names related to Carboxy Methyl Lysine

BCR, RhoGEF and GTPase activating protein (BCR), ALL, BCR1, CML, D22S11, D22S662, PHL

Protein level used designations for Carboxy Methyl Lysine

  • BCR/FGFR1 chimera protein
  • FGFR1/BCR chimera protein
  • breakpoint cluster region protein
  • renal carcinoma antigen NY-REN-26
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