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CAN Products

(Calcineurin (CAN))
catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation [RGD, Feb 2006].

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Featured CAN Categories

CAN Antibodies

High quality antibodies with extensive validation data.

CAN ELISA Kits

Reliable ELISA kits for a wide range of species.

CAN Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CAN Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (10)
Cat. No. ABIN7433471
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN3028953
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN5535597
Quantity 400 μL
Datasheet Datasheet

Recommended CAN ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6954259
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969739
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969738
Quantity 96 tests
Datasheet Datasheet

Recommended CAN Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7393805
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7393802
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2703737
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our CAN products

Kunii, Hino, Matsumoto, Nagaoka, Nawa, Kakita, Akatsu, Hashizume, Yabe: "Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder." in: Scientific reports, Vol. 9, Issue 1, pp. 14877, (2020) (PubMed).

Krenzien, Quante, Heinbokel, Seyda, Minami, Uehara, Biefer, Schuitenmaker, Gabardi, Splith, Schmelzle, Petrides, Azuma, Pratschke, Li, ElKhal, Tullius: "Age-Dependent Metabolic and Immunosuppressive Effects of Tacrolimus." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 17, Issue 5, pp. 1242-1254, (2016) (PubMed).

Vega, Rothermel, Weinheimer, Kovacs, Naseem, Bassel-Duby, Williams, Olson: "Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 669-74, (2003) (PubMed).

Jicha, Weaver, Lane, Vianna, Kress, Rockwood, Davies: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, (1999) (PubMed).

Liang, Venema, Wang, Ju, Venema, Marrero: "Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19846-51, (1999) (PubMed).

Lai, Burnett, Wolosker, Blackshaw, Snyder: "Cain, a novel physiologic protein inhibitor of calcineurin." in: The Journal of biological chemistry, Vol. 273, Issue 29, pp. 18325-31, (1998) (PubMed).

Sík, Hájos, Gulácsi, Mody, Freund: "The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 6, pp. 3245-50, (1998) (PubMed).

Verin, Cooke, Herenyiova, Patterson, Garcia: "Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses." in: The American journal of physiology, Vol. 275, Issue 4 Pt 1, pp. L788-99, (1998) (PubMed).

Husi, Luyten, Zurini: "Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin." in: The Journal of biological chemistry, Vol. 269, Issue 19, pp. 14199-204, (1994) (PubMed).

Fruman, Klee, Bierer, Burakoff: "Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 9, pp. 3686-90, (1992) (PubMed).

Synonyms and alternative names related to CAN

protein phosphatase 3 catalytic subunit alpha (PPP3CA), Calcineurin A1 (CanA1), protein phosphatase 3, catalytic subunit, alpha isoform (Ppp3ca), protein phosphatase 3 catalytic subunit alpha (Ppp3ca), 2900074D19Rik, AI841391, AW413465, CALN, Caln, CALNA, Calna, CALNA1, Calna1, Can, canA, Cana1, CAN A1/PP2B, CCN1, CG1455, CN, CnA, CNA1, CnnA21EF, D14, DmCanA1-100B, Dmel\\CG1455, pMY4, PP2B, PP2B 21EF, PpD14, PPP2B

Protein level used designations for CAN

  • CAM-PRP catalytic subunit
  • calcineurin A alpha
  • calmodulin-dependent calcineurin A subunit alpha isoform
  • protein phosphatase 2B, catalytic subunit, alpha isoform
  • protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
  • serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
  • CG1455-PA
  • CG1455-PB
  • CG1455-PD
  • CanA1-PA
  • CanA1-PB
  • CanA1-PD
  • calcineurin
  • calcineurin A
  • calcineurin A1
  • protein phosphatase D14
  • protein phosphatase from PCR fragment D14
  • PP2B alpha 1
  • PP2BA alpha
  • Calcineurin subunit A alpha
  • protein phosphatase 3, catalytic subunit, alpha isoform
  • protein phosphatase-2Ba
  • calcineurin catalytic subunit delta isoform
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