CADM1 Products
(Cell Adhesion Molecule 1 (CADM1))
Categories
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
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Featured CADM1 Categories
CADM1 Antibodies
High quality antibodies with extensive validation data.
CADM1 ELISA Kits
Reliable ELISA kits for a wide range of species.
CADM1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CADM1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
Cat. No.
ABIN565153
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (2)
- (3)
Cat. No.
ABIN738351
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6260400
Quantity
100 μL
Datasheet
Datasheet
Recommended CADM1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954545
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6810493
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5652756
Quantity
96 tests
Datasheet
Datasheet
Recommended CADM1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274016
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274017
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1347851
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our CADM1 products
: "Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004721, (2015) (PubMed).: "Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity." in: International journal of nanomedicine, Vol. 9, pp. 4829-46, (2014) (PubMed).
: "Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 35170-80, (2012) (PubMed).
: "Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ..." in: Toxicology and applied pharmacology, Vol. 251, Issue 1, pp. 70-8, (2011) (PubMed).
: "Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 22, pp. 10250-5, (2010) (PubMed).
: "Cell adhesion molecule 1: a novel risk factor for venous thrombosis." in: Blood, Vol. 114, Issue 14, pp. 3084-91, (2009) (PubMed).
: "SMAGP, a new small trans-membrane glycoprotein altered in cancer." in: Oncogene, Vol. 23, Issue 19, pp. 3395-403, (2004) (PubMed).
: "SynCAM, a synaptic adhesion molecule that drives synapse assembly." in: Science (New York, N.Y.), Vol. 297, Issue 5586, pp. 1525-31, (2002) (PubMed).
Synonyms and alternative names related to CADM1
cell adhesion molecule 1 (CADM1), cell adhesion molecule 1 L homeolog (cadm1.L), cell adhesion molecule 1 (Cadm1), 2900073G06Rik, 3100001I08Rik, AI987920, BL2, bl2, Bl2, IGSF4, igsf4, Igsf4, IGSF4A, igsf4a, Igsf4a, Necl-2, necl-2, NECL2, necl2, Necl2, RA175, ra175, RA175A, RA175B, RA175C, RA175N, sgIGSF, sgigsf, SgIGSF, ST17, st17, sTSLC-1, stslc-1, SYNCAM, syncam, SynCam, synCAM1, syncam1, SynCAM1, TSLC1, tslc1, Tslc1, xnecl2Protein level used designations for CADM1
- TSLC-1
- TSLC1/Nectin-like 2/IGSF4
- immunoglobulin superfamily member 4
- immunoglobulin superfamily, member 4
- immunoglobulin superfamily, member 4D variant 1
- immunoglobulin superfamily, member 4D variant 2
- nectin-like 2
- nectin-like protein 2
- spermatogenic immunoglobulin superfamily
- synaptic cell adhesion molecule
- truncated CADM1 protein
- tumor suppressor in lung cancer 1
- cell adhesion molecule 1
- NECL-2
- cell adhesion molecule 1 transcript variant 8abc
- immunoglobulin superfamily member 4A
- immunosuperfamily protein Bl2
- immunoglobulin superfamily, member 4A
- secretory isoform of TSLC1
- tumor suppressor in lung cell-1
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